半乳糖缺乏的IgA1在相关肾脏疾病中的研究进展

临床儿科杂志 ›› 2014, Vol. 32 ›› Issue (5): 489-493.

半乳糖缺乏的IgA1在相关肾脏疾病中的研究进展

张钰恒综述，高进审校

内蒙古医科大学附属医院(内蒙古呼和浩特　010059）

收稿日期:2014-01-21 出版日期:2014-05-15 发布日期:2014-05-15

The research progress of galactose-deficient IgA1 in the related kidney diseases

Reviewer: Zhang Yuheng, Reviser: Gao Jin

(Inner Mongolia Medical University, Hohhot 010059 ，Neimenggu ，China)

Received:2014-01-21 Published:2014-05-15 Online:2014-05-15

摘要/Abstract

摘要：

近年来IgA肾病及紫癜性肾炎越来越受到关注，其发病机制尚不明确、诊断标准过于单一、病程长及预后不良等均成为临床亟待解决的问题。IgA肾病和紫癜性肾炎都是与IgA有关的免疫复合物疾病。研究发现在这两种疾病患者血清中半乳糖缺乏的IgA1都显著升高，其水平可能是诊断IgA肾病及紫癜性肾炎的无创性生物标记之一，并在一定程度上可预示疾病预后、监测疾病发展。文章综述了半乳糖缺乏的IgA1的发现、结构、产生过程、可能的致病机制及其作用意义。

Abstract: In recent years, IgA nephropathy and Henoch-Sch?nlein purpura nephritis attract more and more attention on their unclear pathogenesis, single diagnostic criteria, long duration and poor prognosis, etc.. Research suggests that IgA nephropathy and purpura nephritis are IgA immune complex diseases, and serum galactose-deficient is elevated in patients with these two diseases, which might become a noninvasive biomarker for the diagnosis, prognosis prediction and disease development monitoring for IgA nephropathy and purpura nephritis. Galactose-deficient IgA1 is reviewed for its discovery, structure, process, the possible pathogenic mechanism and its significance in details in this paper.

张钰恒，高进. 半乳糖缺乏的IgA1在相关肾脏疾病中的研究进展[J]. 临床儿科杂志, 2014, 32(5): 489-493.

Reviewer: Zhang Yuheng,Reviser: Gao Jin . The research progress of galactose-deficient IgA1 in the related kidney diseases [J]. , 2014, 32(5): 489-493.

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