Abstract: Objective　To investigate the quality of life in children with epilepsy. Methods　Pediatric quality of life inventory measurement models generic core scale (PedsQL) 4.0 was used to evaluate the quality of life in hospitalized children with epilepsy in past three years. At the same time, the healthy children were selected as controls. Results　A total of 152 children with epilepsy had been enrolled, 92 boys and 60 girls, with an average age of (6.79 ± 2.78) years, Another 160 healthy children were selected, 95 boys and 65 girls, with an average age of (7.25±2.45) years. The Cronbach internal consistency coefficient of PedsQL 4.0 was 0.87. The factor analysis presented four dimensions, including physical function, social function, emotional function and school performance, consisting with the original created scale. The score of the quality of life in children with epilepsy was (57.24±4.31), significantly lower than that in healthy children (89.74±9.31) (t=2.71, P<0.05). Conclusions　PedsQL 4.0 can be used to evaluate the quality of life in Chinese children with epilepsy. The quality of life of children with epilepsy is poor.