关键词: 新型冠状病毒； 心电图； 心律失常； 心肌酶谱； 儿童

Abstract: Objective To explore the situation of myocardial injury in children infected with 2019 novel coronavirus (COVID- 19 ). Methods The electrocardiogram and myocardial enzyme spectrum in 33 children with COVID- 19 infection diagnosed by clinical manifestations, lung CT and nucleic acid detection from January 28 , 2020 to March 7 , 2020 were retrospectively analyzed. The children were divided into the mild symptom group and the general symptom group. The differences of arrhythmia status and myocardial enzyme spectrum indexes between the two groups were compared and the correlation between the age of the children and myocardial enzyme spectrum was analyzed. Results Among the 33 children ( 20 boys and 13 girls), 8 ( 24 . 2 %) had arrhythmia and 11 ( 33 . 3 %) had abnormal myocardial enzyme spectrum, all of whom were from the general symptom group. The incidence of arrhythmia in the general symptom group was higher than that in the mild symptom group, and the difference was statistically significant (P< 0 . 05 ). Arrhythmias are often manifested as sinus tachycardia. The abnormal rates of lactate dehydrogenase (LDH), LDH isoenzyme 1 (LD 1 ) and creatine kinase isoenzyme (CK-MB) were 42 . 9 % ( 9 /21 ), 38 . 1 % ( 8 /21 ), and 47 . 6 % ( 10 /21 ) respectively in the general symptom group, which were higher than those in the mild symptom group (all P< 0 . 05 ). The levels of mean LDH, LD 1 , and median CK-MB in the general symptom group were higher than those in the mild symptom group, and the difference was statistically significant (P< 0 . 05 ). The age of children with COVID-19 infection is significantly negatively correlated with the levels of LDH, LD1, CK, and CK-MB (r=-0.563~-0.458, P< 0 . 01 ). Conclusions? Children with COVID- 19 infection have different degrees of myocardial damage. Sinus tachycardia is common manifestation. Multiple indexes of myocardial enzymes are elevated. The myocardial damage was more severe in the younger child with more severe symptoms.

Key words: 2019 -novel coronavirus; electrocardiogram; arrhythmia; myocardial enzyme spectrum; child