临床儿科杂志 ›› 2021, Vol. 39 ›› Issue (9): 715-.doi: 10.3969/j.issn.1000-3606.2021.09.018

• 继续医学教育 • 上一篇    

儿童急性髓系白血病治疗进展

吴珺1,张乐萍2   

  1. 1 .北京大学首钢医院儿科(北京 100144);2 .北京大学人民医院儿科(北京 100044)
  • 出版日期:2021-09-15 发布日期:2021-09-03

Progress in treatment of childhood acute myeloid leukemia

WU Jun1 , ZHANG Leping2   

  1. 1 .Department of Pediatrics, Peking University Shougang Hospital, Beijing 100144 , China; 2 .Department of Pediatrics, People’s Hospital, Peking University, Beijing 100144, China
  • Online:2021-09-15 Published:2021-09-03

摘要: 急性髓系白血病(AML)是由于造血干细胞分化障碍及增殖过度所致异常骨髓造血前体细胞聚集的恶性克 隆性疾病。近年来随着危险度分层的合理应用、靶向药物的不断研发、支持治疗的进步、造血干细胞移植技术的日渐成熟, 儿童AML的生存率已经较前有明显提高。文章综述儿童AML的治疗进展。

关键词: 急性髓系白血病; 治疗; 研究进展; 儿童

Abstract: Acute myeloid leukemia (AML) is a malignant clonal disease in which abnormal bone marrow hematopoietic precursor cells accumulate due to differentiation disorder and excessive proliferation of the hematopoietic stem cells. In recent years, with the rational application of risk stratification, continuous research and development of the targeted drugs, advancement of supportive treatments and maturity of the hematopoietic stem cell transplantation technology, the survival rate of pediatric AML has been significantly improved. This article reviews the progress in the treatment of pediatric AML.

Key words: acute myeloid leukemia; therapy; research advance; child