长双歧杆菌与婴幼儿肠道健康的研究进展

doi:10.12372/jcp.2022.21e0107

摘要/Abstract

摘要：

长双歧杆菌是一种对肠道有益的共生菌,与婴幼儿肠道健康密切相关。文章介绍了长双歧杆菌的生理特性与基因组学、代谢组学和蛋白组学水平的生物学特性,在治疗或缓解婴幼儿胃肠道疾病方面的益生功能,及其在国内外的研究进展与应用发展前景。分析了不同菌株的长双歧杆菌治疗婴幼儿功能性便秘、肠易激综合征和炎症性肠炎的功效作用和可能机制。以期为长双歧杆菌应用于临床治疗或缓解婴幼儿胃肠道疾病提供科学依据,为长双歧杆菌功能性菌株的开发及其用于促进肠道健康的深入研究提供思路。

关键词: 长双歧杆菌, 婴幼儿肠道健康, 功能性便秘, 肠易激综合征, 炎症性肠炎, 基因组学

Abstract:

Bifidobacterium longum is a commensal microbiota beneficial to the intestine, which is closely related to gut health during infancy. This paper reviews the physiological characteristics and the biological characteristics of genomics, metabolomics and proteomics, the prebiotic function in treating or alleviating gastrointestinal diseases in infants, and the research progress and application development prospect at home and abroad of Bifidobacterium longum. This review also analyzes the efficacy and possible mechanism of different strains of Bifidobacterium longum in the treatment of infantile functional constipation, irritable bowel syndrome and inflammatory bowel disease in order to provide scientific basis for the application of Bifidobacterium longum in clinical treatment or alleviation of gastrointestinal diseases in infants, and provide ideas for the development of Bifidobacterium longum functional strains and their in-depth research on promoting intestinal health.

Key words: Bifidobacterium longum, infant intestinal health, functional constipation, irritable bowel syndrome, inflammatory bowel disease, genomics

吴诗寅, 蔡美琴. 长双歧杆菌与婴幼儿肠道健康的研究进展[J]. 临床儿科杂志, 2022, 40(9): 715-720.

WU Shiyin, CAI Meiqin. Advances in Bifidobacterium longum and intestinal health during infancy[J]. Journal of Clinical Pediatrics, 2022, 40(9): 715-720.

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生理特性	菌株
生理特性	性能优良	性能不足
胃肠液耐受能力	B. longum UCD272^[4] B. longum FGDLZ8M1^[9]	B. longum FGDLZ4M1^[9] B. longum FBJ20M1^[10]
肠定殖能力	B. longum ATCC 15697^[4] B. longum AH1206^[11]	B. longum A1^[9] B. longum CCM 372^[10]
低聚糖利用能力	大多数长双歧杆菌能够利用低聚果糖与低聚半乳糖	不能利用低聚果糖：B. longum A1^[9] 不能利用低聚半乳糖：B. longum FBJ9M5^[9]
抗生素抗性	大多数长双歧杆菌菌株对红霉素、庆大霉素、链霉素、四环素、万古霉素和利福平敏感,不具抗性	具有四环素抗性：B. longum CCFM760^[8] 具有卡那霉素抗性：B. longum FGDLZ8M1^[9]
抗氧化能力	B. longum BBMN68^[12]	大多数长双歧杆菌对氧敏感