特应性皮炎相关细胞因子的研究进展

doi:10.3969/j.issn.1000-3606.2019.02.018

临床儿科杂志 ›› 2019, Vol. 37 ›› Issue (2): 148-.doi: 10.3969/j.issn.1000-3606.2019.02.018

特应性皮炎相关细胞因子的研究进展

孔羽薇综述　姚志荣审校

上海交通大学医学院附属新华医院（上海　200092）

出版日期:2019-02-15 发布日期:2019-02-26

Research progress on cytokines in atopic dermatitis

　Revierwer: KONG Yuwei, Reviser: YAO Zhirong

Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China

Online:2019-02-15 Published:2019-02-26

摘要/Abstract

摘要： 特应性皮炎（AD）是慢性易复发高度瘙痒的皮肤炎症性疾病，其发病机制复杂，包括遗传易感性、环境因素、免疫功能改变和皮肤屏障功能障碍等，其中免疫功能异常是AD发病的关键环节。 T淋巴细胞可通过分泌特征性的细胞因子发挥免疫调节作用，不同的T辅助细胞（Th）亚群，如Th2、Th9、Th17和Th22细胞，表达高水平的IL-31、IL-9、IL-10、 IL-17、IL-22等。文章综述不同T淋巴细胞亚群及其产生的细胞因子对AD发病的影响。

关键词: 特应性皮炎；　皮肤屏障功能失调；　T淋巴细胞；　细胞因子

Abstract: 　Atopic Dermatitis (AD) is a highly recurrent and itchy chronic inflammatory disease with a complicated pathogenesis involving genetic susceptibility, environmental factors, immune function deregulations and skin barrier dysfunction. Immunology abnormalities play a significant role in the pathogenesis of AD. T lymphocytes exert immunomodulatory effects by secreting characteristic cytokines. Different T helper cell (Th) subpopulations, such as Th2, Th9, Th17 and Th22 cells, express high levels of IL-31, IL-9, IL-10, IL-17, IL- 22 and so on. The article specifically reviews on the significant effects of different T lymphocyte subsets and the cytokines produced on the pathogenesis of AD.

Key words: atopic dermatitis;　skin barrier dysfunction;　T lymphocytes;　cytokines

孔羽薇. 特应性皮炎相关细胞因子的研究进展[J]. 临床儿科杂志, 2019, 37(2): 148-.

KONG Yuwei. Research progress on cytokines in atopic dermatitis[J]. Journal of Clinical Pediatrics, 2019, 37(2): 148-.

特应性皮炎相关细胞因子的研究进展

Research progress on cytokines in atopic dermatitis

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