ELABELA/Apelin-APJ通路在心血管发育中作用比较

doi:10.12372/jcp.2023.22e0853

摘要/Abstract

摘要：

先天性心脏病是人类最常见的出生缺陷，与胚胎期心血管发育密切相关。ELABELA/Apelin-APJ通路主要包含2个肽配体ELABELA、Apelin以及他们共同的受体APJ。已知ELABELA |Apelin-APJ通路参与了多种生理、病理过程，且与多种疾病的发生密切相关。近年来ELABELA/Apelin-APJ通路与心血管发育之间的关系得到广泛关注。文章主要针对ELABELA/Apelin-APJ通路对心血管发育强大的调控作用进行总结和比较，旨在揭示这两条通路在心脏发育的不同阶段所起的作用，以及在预防先天性心血管畸形方面的意义。

关键词: ELABELA/Apelin-APJ通路, 胚胎干细胞, 心肌分化

Abstract:

Congenital heart disease is the commonest birth defect and is closely related to cardiovascular development during the embryonic period. ELABELA/Apelin-APJ pathway mainly contains two peptide ligands, ELABELA and Apelin, as well as their common receptor APJ. It is known that ELABELA/Apelin-APJ pathway is involved in many physiological and pathological processes and is closely related to the occurrence of many disease. In recent years, the relationship between the ELABELA/Apelin-APJ pathway and cardiovascular development has received extensive attention. This article mainly summarizes and compares the powerful regulatory effects of the ELABELA/Apelin-APJ pathway on cardiovascular development, aiming to reveal the role of the two pathways in different stages of cardiac development and the great significance in preventing congenital cardiovascular malformation.

Key words: ELABELA/Apelin-APJ pathway, embryonic stem cell, cardiomyocyte differentiation

杨俊婕, 孙锟. ELABELA/Apelin-APJ通路在心血管发育中作用比较[J]. 临床儿科杂志, 2023, 41(7): 543-548.

YANG Junjie, SUN Kun. The role of ELABELA/Apelin-APJ pathway in cardiovascular development[J]. Journal of Clinical Pediatrics, 2023, 41(7): 543-548.

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