临床儿科杂志 ›› 2025, Vol. 43 ›› Issue (5): 376-382.doi: 10.12372/jcp.2025.24e1008
收稿日期:
2024-09-23
录用日期:
2024-11-19
出版日期:
2025-05-15
发布日期:
2025-05-09
通讯作者:
姜莉 电子信箱:Received:
2024-09-23
Accepted:
2024-11-19
Published:
2025-05-15
Online:
2025-05-09
摘要:
幼年特发性关节炎相关葡萄膜炎(JIA-U)是16岁以下儿童中一种常见的非感染性自身免疫性葡萄膜炎。其主要发病机制为遗传与环境因素的交互作用,导致机体自身免疫紊乱。在这些因素的共同作用下,JIA患者的自身免疫反应可能会破坏外周免疫耐受以及血-视网膜屏障,导致T、B细胞及其亚群浸润患者的眼组织,通过对特定的视网膜抗原产生反应、产生高度特异性的自身抗体以及分泌肿瘤坏死因子α(TNF-α)、白介素6(IL-6)等细胞因子,促进眼组织炎症的发生发展,严重时威胁患者的视力。治疗采用阶梯式策略,以皮质类固醇为一线药物,联合使用甲氨蝶呤(MTX)进行类固醇减量全身治疗,对于MTX不耐受或疗效不佳的患者,或者出现严重的视力威胁性并发症的患者,可添加或改用生物制剂类改善病情抗风湿药(bDMARDs)。TNF-α抑制剂、IL-6受体抑制剂和Janus激酶抑制剂是针对难治性JIA-U或MTX无反应的患者常用的bDMARDs,此外,T细胞共刺激调节剂和抗CD20单抗也可能对难治性JIA-U或MTX无反应的患者有效。未来研究需进一步探究这些生物制剂在JIA-U中的作用机制及安全性和有效性,以提供更有效的治疗参考。
赵福林, 姜莉. 幼年特发性关节炎相关性葡萄膜炎的发病机制与治疗[J]. 临床儿科杂志, 2025, 43(5): 376-382.
ZHAO Fulin, JIANG Li. Pathogenesis and treatments of juvenile idiopathic arthritis-associated uveitis[J]. Journal of Clinical Pediatrics, 2025, 43(5): 376-382.
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