临床儿科杂志 ›› 2016, Vol. 34 ›› Issue (2): 93-.doi: 10.3969 j.issn.1000-3606.2016.02.003

• 呼吸系统疾病专栏 • 上一篇    下一篇

太原地区急性呼吸道人偏肺病毒和人博卡病毒感染患儿临床特征分析

张云宏1,孙宇2,贾云霞3,刘燕3,兰涛3,赵林清2,钱渊2,朱汝南2,王乃昌4   

  1. 1.山西医科大学(山西太原 030001);2.首都儿科研究所病毒研究室(北京 100020);3.山西医科大学附属人民医院儿科(山西太原 030012);4.山西省疾病预防控制中心病毒研究室(山西太原 030012)
  • 收稿日期:2016-02-15 出版日期:2016-02-15 发布日期:2016-02-15
  • 通讯作者: 兰涛 E-mail:taolan4192@163.com

 人偏肺病毒|人博卡病毒|呼吸道感染|儿童

 ZHANG Yunhong1, SUN Yu2, JIA Yunxia3, LIU Yan3, LAN Tao3, ZHAO Linqing2, QIAN Yuan2, ZHU Runan2, WANG Naichang4   

  1. 1. Shanxi Medical University, Taiyuan 030001, Shanxi, China; 2. Laboratory of Virology, Capital Institute of Pediatrics, Beijing 100020, China; 3. Department of Pediatrics, People’s Hospital Affiliated to Shanxi Medical University, Taiyuan 030012, Shanxi, China; 4. Laboratory of Virology , Center for Disease Control and Prevention of Shanxi Province, Taiyuan 030012, Shanxi , China
  • Received:2016-02-15 Online:2016-02-15 Published:2016-02-15

摘要: 目的 了解太原地区急性呼吸道感染(ARTIs)儿童人偏肺病毒(hMPV)与人博卡病毒(HBoV)的感染情况及其临床和流行病学特征。方法 采集2012 年11 月—2013 年5 月及2013 年11 月—2014 年5 月就诊的ARTIs 患儿549 例,采集咽拭子标本,应用实时PCR 方法检测hMPV 与HBoV。结果 549 例患儿的咽拭子标本中hMPV 阳性56 例(10.2%),HBoV 阳性15 例(2.7%)。其中2012 年11 月—2013 年5 月hMPV 与HBoV 检出率分别为12.3% 和2.0%,2013 年11 月—2014 年5 月hMPV 与HBoV 检出率分别为6.5% 和4.0%,两时间段hMPV 检出率差异有统计学意义(P<0.05),HBoV 检出率差异无统计学意义(P>0.05);不同月份hMPV、HBoV 检出率差异无统计学意义(P>0.05)。hMPV 与HBoV 均在<2 岁组中检出率最高。hMPV 在喘息性支气管炎与毛细支气管炎患儿中检出率最高。结论 太原地区 hMPV 和HBoV 与部分儿童尤其是婴幼儿ARTIs 有关,hMPV 是诱发部分婴幼儿喘息性疾病的重要病原体之一。

Abstract: Objective  To investigate the status and clinical and epidemiological characteristics of human metapneumovirus (hMPV) and human bocavirus (HBoV) infections in children with acute respiratory tract infections (ARTIs) in Taiyuan. Methods A total of 549 children with ARTIs from November 2012 to May 2013 and November 2013 to May 2014 were recruited. The pharyngeal swab specimens were collected. The hMPV and HBoV were detected by using real-time PCR. Results In 549 children, 56 children (10.2%) were hMPV positive on swab specimens, 15 children (2.7%) were HBoV positive on swab specimens. The detection rates of hMPV and HBoV in November 2012 to May 2013 were 12.3% and 2.0%, respectively, and in November 2013 to May 2014 were 6.5% and 4.0%, respectively. The detection rate of hMPV was significantly different between two periods (P<0.05), while the detection rate of HBoV has no significant difference between two periods. In different months, the detection rate of hMPV and HBoV showed no significant difference. The highest detection rates of hMPV and HBoV were all in children younger than two years old. The highest detection rate of hMPV was in children with asthmatic bronchitis or bronchiolitis. Conclusion In Taiyuan, during the monitoring periods, the ARITS are associated with childhood hMPV and HBoV infection especially in infants and toddlers. hMPV is one of the most important pathogens in infants and toddlers with wheezing.