目的　探讨特应质孕母所生婴儿发生特应性疾病的风险。方法　应用ELISA法检测33例特应质孕母（特应 质组）及44例非特应质孕母（非特应质组）所生新生儿脐血中巨噬细胞源性趋化因子（CCL22）与总IgE水平，分析两者之 间相关性；并对入选新生儿进行定期随访，观察其特应性疾病发生风险。结果　特应质组脐血CCL22水平高于非特应质 组，差异有统计学意义（P<0.01）；以≥0.9 kU/L为脐血总IgE水平升高的阈值，特应质组（11/33）阳性率明显高于非特 应质组（4/44），差异有统计学意义（P<0.01）；特应质组及非特应质组婴儿的脐血CCL22和IgE水平之间均呈显著正相关 （r=0.808、0.348， P均<0.05）；在12个月的随访期间，特应质组婴儿的特应性疾病发生率（24/33）明显高于非特应质组 （10/44），差异有统计学意义（P<0.01）；脐血CCL22和总IgE与婴儿特应性疾病发生有相关性（P<0.01）。 结论　特应质 孕母所生新生儿出生时已处于致敏状态有潜在发生特应性疾病倾向的可能；脐血CCL22联合IgE水平检测，对预测特应 性疾病发生风险可能更具有临床意义。

Objective　To investigate the risk of atopic disease in infants with a atopic mothers. Methods　The level of CCL22 and total IgE in the cord blood were measured using ELISA for 33 newborns with atopic mothers and for 44 newborns with non-atopic mothers. Correlation between the two factors was examined. Periodic follow-ups were conducted on the newborns to observe the risk of atopic diseases. Results  The atopic group showed a higher level of CCL22 than that in nonatopic group, and the difference was statistically significant (Z=5.20, P=0.000). When 0.9 kU/L was taken as the threshold of an elevated IgE level in cord blood, the positive rates of the atopic group (11/33) was much higher than that of the non-atopic group (4/44) (χ2=7.07, P=0.008). Furthermore, the level of CCL22 and the level of IgE were significantly positively correlated (r=0.808, P=0.000; r=0.348, P=0.021) in the atopic group and the non-atopic group, respectively. During the 12 months of follow-up, the number of atopic diseases occurred in the infants in the atopic group (24/33) was much higher than that in the non-atopic group (10/44) (χ2=19.12, P<0.001).Significant correlation exists between levels CCL22 and total IgE in cord blood and infant atopic diseases (Z=5.36, P=0.000; Z=4.44, P=0.000). Conclusions　At birth, the infants with an atopic mother are already in a sensitization state and have a tendency to develop potential atopic diseases. There is a correlation between the history of atopic diseases in the mothers and the elevated level of CCL22 in the cord blood of the newborns, and the probability of developing atopic diseases for the newborns is significantly higher when the level of CCL22 is elevated. The combined detection of CCL22 and IgE levels impact significantly on the prediction of the risk of atopic diseases clinically.