血管迷走性晕厥（VVS）是小儿不明原因晕厥中最常见的原因。VVS病因复杂，其诊断主要通过临床表现及 直立倾斜试验（HUT）。 目前有研究指出，神经内分泌系统在晕厥的发病机制中发挥重要作用，HUT诱发晕厥时伴有异常 的神经体液激活。VVS患儿内皮系统分泌的血管内皮素1、一氧化氮等在VVS晕厥发生前后存在血浆浓度改变，提示内皮 系统参与儿童VVS的发生。文章综述关于血管内皮系统参与儿童VVS发病机制方面的研究。

　Vasovagal syncope (VVS) is the most common cause of unexplained syncope in children. The etiology of VVS is complex, and its diagnosis is mainly based on clinical manifestations and head-up tilt test (HUT). It has been pointed out that neuroendocrine system plays an important role in the pathogenesis of syncope. HUT-induced syncope is accompanied by abnormal neurohumoral activation. The changes of plasma concentration of endothelin-1 and nitric oxide secreted by endothelial system before and after VVS syncope in children suggest that endothelial system is involved in the occurrence of VVS in children. This article reviews the research on the involvement of vascular endothelial system in the pathogenesis of VVS in children.