目的　探讨IL-17F基因多态性和哮喘易感性、IL-17水平的关系。方法　选择133例哮喘患儿和114例对照 儿童，测定IL-17F基因rs763780、rs1889570位点多态性，并分析其与儿童支气管哮喘易感性及外周血IL-17水平的相关性。 结果　哮喘组和对照组两组间等位基因、基因型频数分布在rs1889570位点的差异有统计学意义（P=0.049、 P=0.043）， 哮喘组携带A等位基因者明显高于对照组（OR=1.43，95%CI：1.001~2.004， P=0.049）；rs763780位点等位基因、基因型 分布在两组间的差异均无统计学意义（P>0.05）。 哮喘组rs763780和rs1889570位点各基因型间IL-17水平差异均无统计 学意义（P>0.05）。 结论　IL-17F基因rs1889570位点与儿童哮喘易感性有关，携带A等位基因者发生哮喘的危险性高。

　Objective　To explore the relationship of IL-17F gene polymorphism with asthma susceptibility and IL-17F level. Method　The single nucleotide polymorphisms of rs763780 and rs1889570 in IL-17F gene were determined in 133 asthma children and 114 control children, and the correlation among the polymorphisms and the susceptibility and peripheral blood IL17 level in children with bronchial asthma were analyzed. Results　The frequency of alleles and genotypes in rs1889570 were significantly different between asthma patients and healthy controls (P=0.049, P=0.043). The A allele frequency of rs1889570 in asthma group was significantly higher than that in control group (OR=1.43, 95%CI: 1.001~2.004, P=0.049). The frequency of alleles and genotypes in rs763780 between two groups had no significant difference (P>0.05). There was no difference in IL-17 levels between rs763780 and rs1889570 genotypes in asthma group (P>0.05). Conclusion　The rs1889570 locus of IL-17F gene is associated with the susceptibility to asthma in children and those who carry the A allele are at high risk of asthma.