局灶节段性肾小球硬化（FSGS）临床主要表现为蛋白尿和肾病综合征，病理以局灶节段分布的肾小球硬化及 足细胞的足突融合为特征，是导致终末期肾脏病的主要原因之一。由于FSGS病因复杂，发病机制也尚未明确，其诊断及 治疗还面临很多困难。文章综述近年来FSGS的诊治现状。

　The main clinical manifestations of focal segmental glomerulosclerosis (FSGS) are proteinuria and nephrotic syndrome. FSGS is pathologically characterized by focal segmental distribution of glomerular sclerosis and podocyte foot process fusion, and is one of the main causes of end-stage renal disease. Due to the complex etiology and unclear pathogenesis of FSGS, its diagnosis and treatment still face many difficulties. This article reviews the current status of diagnosis and treatment of FSGS in recent years.