目的 分析儿童药物性胆管消失综合征（VBDS）的临床特点及病理。方法 收集 2019年1月至2019年12月 收治的3例诊断为药物性VBDS患儿的临床资料，并结合文献进行分析。结果 3例患儿，女1例、男2例，年龄9月龄~8岁， 临床均以黄疸型胆汁淤积伴瘙痒为主要表现；予护肝、退黄，以及免疫抑制剂等治疗，其中2例经治疗3个月后临床症状 及生化指标基本恢复；1例治疗1年余仍有轻度的黄疸型胆汁淤积表现，仍在随诊中。结论 早期识别药物相关性VBDS， 停用相关药物并予积极治疗能改善预后。

Objective To explore the clinical features and pathology of drug-induced vanishing bile duct syndrome (VBDS) in children. Method The clinical data of drug-induced VBDS in 3 children from January 2019 to December 2019 were collected and analyzed in combination with the literature. Results Three children ( 1 girl and 2 boys) aged from 9 months to 8 years had jaundice cholestasis with pruritus as main clinical manifestations. All the patients were treated with liver protection, anti-jaundice and immunosuppression. After 3 months of treatment, the clinical symptoms and biochemical indexes of 2 patients were basically recovered. One patient still presented mild jaundice cholestasis after 1 year of treatment and was still in follow-up. Conclusion? Early identification of drug-related VBDS, discontinuation of related drugs and active treatment can improve the prognosis.