骨桥蛋白（OPN）是近年来备受关注的一种高度磷酸化，具有O-糖基化修饰的酸性蛋白。根据OPN在体内的 分布，可分为分泌型OPN和细胞内OPN，可由体内多种组织细胞合成或分泌，广泛存在于骨、肾、脑、肌肉等多种组织和 细胞中。近年的研究发现，乳汁尤其是初乳中分泌型OPN含量高，且分泌型OPN在生命早期的肠道生长、免疫调节、神经 系统发育中发挥着重要作用。本文综述乳汁中OPN对生命早期生长发育和健康作用的研究进展。

Osteopontin (OPN) is a highly phosphorylated acidic protein with O-glycosylation modification and has attracted much attention in recent years. According to the distribution of OPN in the body, it can be divided into secreted OPN and intracellular OPN. It can be synthesized or secreted by a variety of tissues and cells in the body, and widely exists in bone, kidney, brain, muscle and other tissues and cells. Recent studies have found that secretory OPN is high in breast milk, especially in colostrum, and that secretory OPN plays an important role in intestinal growth, immune regulation and nervous system development in early life. This article reviews the research progress in the effects of OPN in milk on early life growth and health.