嗜碱性粒细胞在过敏性疾病中研究进展及临床应用展望
收稿日期: 2022-01-20
网络出版日期: 2022-08-09
基金资助
国家自然基金面上项目(82170025);上海市卫生健康委员会面上项目(202040166);“交大之星”计划医工交叉研究基金(YG2022QN038)
Research progress and prospect of clinical application of basophils in allergic diseases
Received date: 2022-01-20
Online published: 2022-08-09
Th2免疫应答是过敏性疾病发病最重要的免疫学机制。嗜碱性粒细胞(Ba)在过敏性炎症中起着始动者、效应者和调节者作用。在过敏性炎症的始动阶段,Ba可能通过独立或与树突状细胞(DCs)间通过协同作用完成抗原递呈作用而启动Th2免疫应答。Ba还表现出增强记忆性Th2、Th17免疫应答的免疫学效应,提示其在记忆性免疫应答中起着重要作用。临床研究发现嗜碱性粒细胞活化试验(basophil activation test,BAT)在过敏性疾病诊断中具有独特优势,且在监测评估特异性免疫治疗和生物制剂治疗疗效中具有作为生物学标记的潜在价值。
关键词： Th2免疫应答; 过敏性疾病; 嗜碱性粒细胞; 嗜碱性粒细胞活化试验
钟文伟 , 李京阳 , 耿丽婷 , 张建华 . 嗜碱性粒细胞在过敏性疾病中研究进展及临床应用展望[J]. 临床儿科杂志, 2022 , 40(8) : 566 -572 . DOI: 10.12372/jcp.2022.22e0131
Th2 immune response is the most important immunological mechanism in the pathogenesis of allergic diseases. Basophil (Ba) plays the role of initiator, effector and regulator in allergic inflammation. In the initial stage of allergic inflammation, Ba may initiate Th2 immune response independently or coordinate with dendritic cells by its antigen presentation function. Ba also shows the immunological effect of enhancing memory Th2 and Th17 immune response, indicating that Ba may also play an important role in memory immune response. Clinical studies have found that Ba activation test has unique advantages in the diagnosis of allergic diseases, and has potential value as a biological marker in monitoring and evaluating the efficacy of specific immunotherapy and biological agent treatment.
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