儿童腺病毒感染与肝脏损害的临床病例及病因探讨
收稿日期: 2022-07-04
网络出版日期: 2024-03-06
Clinical and etiological analysis of adenovirus infection and liver damage in children
Received date: 2022-07-04
Online published: 2024-03-06
张颖 综述 , 许红梅 审校 . 儿童腺病毒感染与肝脏损害的临床病例及病因探讨[J]. 临床儿科杂志, 2024 , 42(3) : 259 -263 . DOI: 10.12372/jcp.2024.22e0909
Human adenovirus infection in children is a common clinical disease that may be life-threatening. Since its discovery, the virus has been found all over the world and can occur in all four seasons. Recently, there have been a number of cases of unexplained severe hepatitis in children. Some of the children were treated with liver transplantation due to their critical condition. The occurrence of the disease may be related to adenovirus infection. This article summarizes the cases of adenovirus infection complicated by liver damage in children that have been reported in the last ten years, and explores their etiology.
Key words: adenovirus infection; abnormal liver function; child
[1] | Dotan M, Zion E, Bilavsky E, et al. Adenovirus can be a serious, life-threatening disease, even in previously healthy children[J]. Acta Paediatr, 2022, 111(3): 614-619. |
[2] | Wen X, Zhang L, Zhao S, et al. High-throughput screening and identification of human adenovirus type 5 inhibitors[J]. Front Cell Infect Microbiol, 2021, 11: 767578. |
[3] | Reddy VS, Barry MA. Structural organization and protein-protein interactions in human adenovirus capsid[J]. Subcell Biochem, 2021, 96: 503-518. |
[4] | Dodge MJ, Macneil KM, Tessier TM, et al. Emerging antiviral therapeutics for human adenovirus infection: recent developments and novel strategies[J]. Antiviral Res, 2021, 188: 105034. |
[5] | Yu X, Ma Y, Gao Y, et al. Epidemiology of adenovirus pneumonia and risk factors for bronchiolitis obliterans in children during an outbreak in Jilin, China[J]. Frontiers in pediatrics, 2021, 9: 722885. |
[6] | Lynch JP, 3rd, Kajon AE. Adenovirus: epidemiology, global spread of novel serotypes, and advances in treatment and prevention[J]. Semin Respir Crit Care Med, 2016, 37(4): 586-602. |
[7] | Zou L, Yi L, Yu J, et al. Adenovirus infection in children hospitalized with pneumonia in Guangzhou, China[J]. Influenza Other Respir Viruses, 2021, 15(1): 27-33. |
[8] | Lu Z, Wang H, Bao Y, et al. Retrospective study of an adenovirus pneumonia outbreak in Shenzhen in 2017[J]. Virol Sin, 2021, 36(3): 555-558. |
[9] | Li L, Woo YY, De Bruyne JA, et al. Epidemiology, clinical presentation and respiratory sequelae of adenovirus pneumonia in children in Kuala Lumpur, Malaysia[J]. PLoS One, 2018, 13(10): e0205795. |
[10] | 曾强, 赵丹洋, 颉雅苹, 等. 2015—2019年广州地区住院患儿人腺病毒感染的流行病学特征[J]. 临床肺科杂志, 2021, 26(11): 1634-1638. |
[11] | Akello JO, Kamgang R, Barbani MT, et al. Genomic analyses of human adenoviruses unravel novel recombinant genotypes associated with severe infections in pediatric patients[J]. Scientific Reports, 2021, 11(1): 24038. |
[12] | Xie L, Zhang B, Zhou J, et al. Human adenovirus load in respiratory tract secretions are predictors for disease severity in children with human adenovirus pneumonia[J]. Virol J, 2018, 15(1): 123. |
[13] | 徐磊, 李国强. 人腺病毒感染防治进展[J]. 西南军医, 2021, 23(3): 243-247. |
[14] | 刘成军, 王华华, 李静, 等. 重症腺病毒肺炎患儿的临床和胸部影像学特征分析[J]. 华中科技大学学报(医学版), 2012, 41(3): 379-381. |
[15] | 吴佩琼, 余嘉璐, 江文辉, 等. 2011年至2014年住院儿童急性呼吸道腺病毒感染临床分析[J]. 国际儿科学杂志, 2016, 43(8): 658-661. |
[16] | 张伟东, 寇丽, 王幸丽, 等. 重度腺病毒肺炎儿童临床症状、血生化指标及影像学表现分析[J]. 中国CT和MRI杂志, 2020, 18(4): 50-53. |
[17] | 郑健斌, 陶建平, 张剑珲, 等. 腺病毒与合胞病毒肺炎患儿的临床特征比较[J]. 广东医学, 2015, (4): 569-571. |
[18] | 黄崇刚, 成黎, 宋亚娣. 小儿重症腺病毒肺炎合并其他病原体感染特征及高危因素探讨[J]. 河北医科大学学报, 2019, 40(10): 1221-1225. |
[19] | 李攀, 郎艳美, 石艳玺. 2015年—2018年住院患儿腺病毒和合胞病毒肺炎的临床特征分析[J]. 中国病案, 2019, 20(11): 93-96. |
[20] | Shi J, Zhou Y, Wang F, et al. A case series of children with adenovirus pneumonia: three-year experiences in a tertiary PICU[J]. BMC Pediatr, 2020, 20(1): 375. |
[21] | 陈伟, 周浩泉. 重症腺病毒肺炎患儿生化指标表达水平及近期预后危险因素研究[J]. 临床肺科杂志, 2021, 26(3): 335-339. |
[22] | 樊映红, 谢诚, 王丽. 88例儿童腺病毒肺炎胸部MSCT影像征象及其临床特征研究[J]. 中国CT和MRI杂志, 2020, 18(12): 71-73. |
[23] | 李少宁, 郑方芳, 符佳, 等. 65例儿童腺病毒肺炎临床特征及其CT影像学表现[J]. 中国CT和MRI杂志, 2018, 16(12): 47-49. |
[24] | 黄娇甜, 卢秀兰, 祝益民, 等. 儿童重症腺病毒肺炎的临床特征及混合感染的高危因素分析[J]. 中国小儿急救医学, 2021, 28(9): 756-762. |
[25] | 李文静, 皮丹丹, 颜密, 等. 重庆西南地区儿童重症腺病毒肺炎死亡的危险因素分析[J]. 中华实用儿科临床杂志, 2022, 37(4): 265-268. |
[26] | 王彩云, 刘娟娟, 米芋枚, 等. 儿童呼吸道腺病毒感染488例临床特征和流行病学分析[J]. 中华临床感染病杂志, 2021, 14(2): 121-126. |
[27] | 齐霁, 张圳, 李玉梅. 儿童腺病毒肺炎26例临床分析[J]. 中国小儿急救医学, 2019, 26(10): 782-784. |
[28] | 曾佩, 汪明辉, 胡榕, 等. 儿童重症腺病毒肺炎的临床特点及其肺功能分析[J]. 中国医师杂志, 2021, 23(5): 768-771. |
[29] | 黄晶晶, 袁林, 卓志强, 等. 儿童7型腺病毒肺炎20例临床特征分析[J]. 中国实用医刊, 2020, 47(7): 18-21. |
[30] | 黄浩, 陈瑜, 马丽娅, 等. 儿童重症腺病毒肺炎的临床特征及高危因素分析[J]. 中华儿科杂志, 2021, 59(1): 14-19. |
[31] | 徐恩会, 袁林, 卓志强, 等. 儿童重症腺病毒肺炎的危险因素分析[J]. 中国实用医刊, 2020, 47(24): 19-21. |
[32] | 阳池娇, 白珺, 潘志伟, 等. 儿童重症腺病毒肺炎与重症肺炎支原体肺炎临床特征及预后比较[J]. 中国医学创新, 2020, 17(11): 145-149. |
[33] | 李莎, 欧榕琼, 王海燕, 等. 儿童重症7B型腺病毒肺炎3例临床分析[J]. 岭南急诊医学杂志, 2022, 27(1): 61-64. |
[34] | Khalifa A, Andreias L, Velpari S. Adenovirus hepatitis in immunocompetent adults[J]. J Investig Med High Impact Case Rep, 2022, 10: 23247096221079192. |
[35] | Ronan BA, Agrwal N, Carey EJ, et al. Fulminant hepatitis due to human adenovirus[J]. Infection, 2014, 42(1): 105-111. |
[36] | Schaberg KB, Kambham N, Sibley RK, et al. Adenovirus hepatitis: clinicopathologic analysis of 12 consecutive cases from a single institution[J]. Am J Surg Pathol, 2017, 41(6): 810-819. |
[37] | Matoq A, Salahuddin A. Acute hepatitis and pancytopenia in healthy infant with adenovirus[J]. Case Rep Pediatr, 2016, 2016: 8648190. |
[38] | Marsh K, Tayler R, Pollock L, et al. Investigation into cases of hepatitis of unknown aetiology among young children, Scotland, 1 January 2022 to 12 April 2022[J]. Euro Surveill, 2022, 27(15): 2200318. |
[39] | Baker JM, Buchfellner M, Britt W, et al. Acute hepatitis and adenovirus infection among children - Alabama, October 2021-February 2022[J]. MMWR Morb Mortal Wkly Rep, 2022, 71(18): 638-640. |
[40] | Mendez-Sanchez N, Pal SC. Editorial: acute hepatitis of unknown origin in children. is autoimmunity at play?[J]. Med Sci Monit, 2022, 28: e937371. |
[41] | Ali S, Prakash S, Murali AR. Hepatic manifestations of nonhepatotropic infectious agents including severe acute respiratory syndrome coronavirus-2, adenovirus, herpes simplex virus, and coxiella burnetii[J]. Gastroenterol Clin North Am, 2021, 50(2): 383-402. |
[42] | Oh JS, Choi JS, Lee YH, et al. The relationships between respiratory virus infection and aminotransferase in children[J]. Pediatr Gastroenterol Hepatol Nutr, 2016, 19(4): 243-250. |
[43] | Saini K, Bolia R, Bhat NK. Incidence, predictors and outcome of sepsis-associated liver injury in children: a prospective observational study[J]. Eur J Pediatr, 2022, 181(4): 1699-1707. |
[44] | Xu N, Chen P, Wang Y. Evaluation of risk factors for exacerbations in children with adenoviral pneumonia[J]. BioMed Research International, 2020: 4878635. |
/
〈 |
|
〉 |