托珠单抗治疗造血干细胞移植后大量心包积液2例报告
收稿日期: 2023-09-02
网络出版日期: 2024-07-08
基金资助
广东省高水平临床重点专科（深圳市配套建设经费)(SZGSP012);深圳市医学重点学科建设经费(SZXK034)
Successful treatment of massive pericardial effusion after hematopoietic stem cell transplantation with tocilizumab: two cases report
Received date: 2023-09-02
Online published: 2024-07-08
李越 , 周小辉 , 王晓东 , 杨春兰 , 王春静 , 张瑜 , 刘四喜 . 托珠单抗治疗造血干细胞移植后大量心包积液2例报告[J]. 临床儿科杂志, 2024 , 42(7) : 595 -599 . DOI: 10.12372/jcp.2024.23e0861
To explore the efficacy and safety of interleukin-6 receptor monoclonal antibody (tocilizumab) in patients with glucocorticoid-resistant/recurrent massive pericardial effusion after hematopoietic stem cell transplantation. The clinical data, diagnosis, treatments, and outcomes of 2 children with β-thalassemia major complicated by massive pericardial effusion after hematopoietic stem cell transplantation were analyzed retrospectively. One case of pericardial effusion was glucocorticoid-resistant and 1 case was recurrent. The pericardial effusion was resolved rapidly after administration of tocilizumab without significant adverse effects, the course of glucocorticoid therapy was shortened, and there was no recurrence of pericardial effusions during subsequent follow-up. Tocilizumab may be considered as a second-line option for patients with glucocorticoid-resistant or recurrent massive pericardial effusion after hematopoietic stem cell transplantation.
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