儿童炎症性肠病的精准治疗研究与应用
收稿日期: 2024-05-16
录用日期: 2024-08-12
网络出版日期: 2025-02-27
基金资助
国家重点研发计划课题(2022YFC2703603);2022年度首都卫生发展科研专项(2022-2-2094);北京市医院管理中心“登峰”人才培养计划(DFL20221003)
Application of precision therapy in pediatric inflammatory bowel disease
Received date: 2024-05-16
Accepted date: 2024-08-12
Online published: 2025-02-27
儿童炎症性肠病（IBD）是一种慢性复发性肠道炎性疾病，其病因不明，发病机制复杂，目前在诊治方面仍然面临挑战。IBD严重影响患儿的生长发育和生活质量，并可能对患儿的心理和社会行为产生不良影响，给社会带来巨大的经济负担。近年来，我国儿童IBD的发病率呈上升趋势，引起了儿科医师的高度重视。建立儿童IBD的精准治疗新模式成为国内外儿科医师和学者的目标。精准医学已被证明在肿瘤、新生儿遗传病的早期筛查与诊断等领域中发挥了重要作用，同时也为儿童IBD的治疗提供了新的方法和视角。本文就当前精准治疗在儿童IBD中的应用情况，阐明精准治疗在儿童IBD治疗中的作用。
贾双珍 , 孔琰 , 刘前超 , 朱艾琳 , 吴捷 . 儿童炎症性肠病的精准治疗研究与应用[J]. 临床儿科杂志, 2025 , 43(3) : 226 -232 . DOI: 10.12372/jcp.2025.24e0499
Pediatric inflammatory bowel disease (IBD) is a chronic, recurrent inflammatory condition of the intestines with unknown etiology and complex pathogenesis, posing significant challenges in diagnosis and treatment. IBD severely impacts the growth and development of affected children, diminishes their quality of life, and may negatively influence their psychological and social behavior, imposing a substantial economic burden on society. In recent years, the incidence of pediatric IBD in China has been on the rise, drawing significant attention from pediatricians. Establishing a new model of precision therapy for pediatric IBD has become a goal for pediatricians and scholars worldwide. Precision medicine has proven effective in early screening and diagnosis of cancers and neonatal genetic diseases, providing new methods and perspectives for the treatment of pediatric IBD. This paper reviews the current application of precision therapy in pediatric IBD, elucidating its role in the treatment of pediatric IBD.
Key words： inflammatory bowel disease; precision therapy; treatment strategies; child
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