目的 探讨妊娠期糖尿病（GDM）对不同孕周孕妇和新生儿脂代谢以及胎盘脂肪转运酶表达的影响。方法 回顾性分析2022年1月至2022年12月住院分娩孕妇及其新生儿的临床资料，采集2023年8月至2023年10月分娩孕妇的胎盘。根据孕妇是否罹患GDM分为GDM组和对照组，比较两组间孕妇及其新生儿脂代谢指标差异；比较两组间胎盘组织内皮脂肪酶（EL）及脂蛋白脂肪酶（LPL）表达差异。结果 纳入足月妊娠孕妇共541例，对照组418例、GDM组123例；早产孕妇共203例，GDM组110例、对照组93例。在足月妊娠孕妇中，与对照组比较，GDM组孕妇孕期增重更多、剖宫产率更高，差异存在统计学意义（P<0.05）；但早产孕妇中，GDM组孕妇较对照组分娩孕周更小、孕期增重也较少，差异有统计学意义（P<0.05）。在足月和早产孕妇中，GDM组分娩前三酰甘油（TG）均高于对照组，高密度脂蛋白胆固醇（HDL）均低于对照组，差异有统计学意义（P<0.05）。GDM组足月新生儿77例入住NICU，按照孕周及出生日期1︰1比例匹配77例入住NICU的新生儿作为对照组，其血总胆固醇（TC）、TG均高于对照组，HDL低于对照组，差异有统计学意义（P<0.05）。在足月妊娠孕妇的胎盘中，GDM组EL表达量较对照组升高，差异有统计学意义（P<0.05），但两组间LPL表达差异无统计学意义（P>0.05）；而早产分娩孕妇中，两组间EL和LPL表达差异均无统计学意义（P>0.05）。结论 GDM与母孕期脂代谢紊乱相关，但仅在足月新生儿中存在相关；胎盘EL可能参与了GDM孕妇所分娩的足月新生儿的脂代谢紊乱的发生。

Objective To explore the impact of gestational diabetes mellitus (GDM) on lipid metabolism in pregnant women and neonates at different gestational weeks, as well as the expression of placental lipid transport enzymes. Methods A retrospective analysis was conducted on clinical data from pregnant women and their neonates who delivered between January 2022 and December 2022. Placentas were collected from women who delivered between August 2023 and October 2023. Participants were divided into a GDM group and a control group based on the presence or absence of GDM. The serum lipids were compared between the two groups for both pregnant women and neonates. Additionally, differences in the expression of endothelial lipase (EL) and lipoprotein lipase (LPL) in placental tissue were compared between the two groups. Results A total of 541 full-term pregnant women were included, with 123 in the GDM group and 418 in the control group. There were 203 pregnant women with premature delivery, with 110 in the GDM group and 93 in the control group. Among full-term pregnant women, compared with the control group, the GDM pregnancies had greater weight gain and a higher rate of cesarean section, and the differences were statistically significant (P<0.05). However, the premature pregnant women with GDM had a smaller gestational age at delivery and less weight gain during pregnancy than those in the control group (P<0.05). Both in full-term and premature pregnancies, compared with the control group, triacylglycerol (TG) was higher and high-density lipoprotein cholesterol (HDL) was lower in the GDM group before delivery, and the difference was statistically significant (P<0.05). In GDM group, 77 full-term newborns were admitted to NICU, and 77 newborns were matched according to gestation week and birth date at a 1:1 ratio as control group; Total cholesterol (TC) and TG in the GDM group were higher than those in the control group, while HDL was lower than that in the control group, and the difference was statistically significant (P<0.05). In the placentas of full-term pregnant women, the expression of EL in the GDM group was significantly increased (P<0.05), but there was no difference in LPL expression between the two groups (P>0.05). In pregnant women with premature delivery, both EL and LPL had no differences in expression between the two groups (P>0.05). Conclusions GDM was associated with lipid metabolism disorders during pregnancy, but only in full-term newborns. Placental EL may be involved in the occurrence of lipid metabolism disorders in full-term newborns delivered by GDM mothers.