目的 探讨肺移植治疗中毒性表皮坏死松解症/Stevens-Johnson 综合征继发性闭塞性细支气管炎的疗效。 方法 回顾性分析既往收治的2例中毒性表皮坏死松解症/Stevens-Johnson 综合征继发性闭塞性细支气管炎患儿的病历资料。结果 2例患者成功接受了肺移植手术且术后未见复发，其中1例术后16个月因感染死亡。文献检索出6例符合要求的患者资料，截至文献发表时均存活且未见疾病复发。结论 肺移植可能是治疗中毒性表皮坏死松解症/Stevens-Johnson 综合征继发性闭塞性细支气管炎的有效手段，可能具有良好的预后，围术期肺部感染的控制是关键。

Objective To assess the efficacy of lung transplantation in managing bronchiolitis obliterans resulting from toxic epidermal necrolysis/Stevens-Johnson syndrome. Methods The medical records of 2 children with toxic epidermal necrolysis/Stevens-Johnson syndrome secondary bronchiolitis obliterans were retrospectively analyzed. Results Two patients successfully underwent lung transplantation and experienced no recurrence of their condition postoperatively. Tragically, one of these patients succumbed to an infection 16 months following the procedure. Additionally, we extracted data on six patients from the literature who fulfilled the criteria, and at the time of publication, all were reported to be alive and free from disease recurrence. Conclusions Lung transplantation emerges as a potentially effective therapeutic option for patients with toxic epidermal necrolysis/Stevens-Johnson syndrome who develop secondary bronchiolitis obliterans, suggesting a favorable prognosis. However, the crux of success lies in meticulous management of perioperative pulmonary infections.