关键词: 肺移植, 中毒性表皮坏死松解症, Stevens-Johnson 综合征, 闭塞性细支气管炎

Abstract:

Objective To assess the efficacy of lung transplantation in managing bronchiolitis obliterans resulting from toxic epidermal necrolysis/Stevens-Johnson syndrome. Methods The medical records of 2 children with toxic epidermal necrolysis/Stevens-Johnson syndrome secondary bronchiolitis obliterans were retrospectively analyzed. Results Two patients successfully underwent lung transplantation and experienced no recurrence of their condition postoperatively. Tragically, one of these patients succumbed to an infection 16 months following the procedure. Additionally, we extracted data on six patients from the literature who fulfilled the criteria, and at the time of publication, all were reported to be alive and free from disease recurrence. Conclusions Lung transplantation emerges as a potentially effective therapeutic option for patients with toxic epidermal necrolysis/Stevens-Johnson syndrome who develop secondary bronchiolitis obliterans, suggesting a favorable prognosis. However, the crux of success lies in meticulous management of perioperative pulmonary infections.

Key words: lung transplantation, toxic epidermal necrolysis, Stevens-Johnson syndrome, bronchiolitis obliterans