13例儿童博卡病毒肺炎合并塑型性支气管炎的临床与影像特点
收稿日期: 2025-05-16
录用日期: 2025-09-23
网络出版日期: 2025-11-06
基金资助
天津市自然科学基金(20JCZDJC00630);天津市医学重点学科(专科)建设项目(TJYXZDXK-040A)
Clinical and imaging features of children with bocavirus pneumonia associated with plastic bronchitis
Received date: 2025-05-16
Accepted date: 2025-09-23
Online published: 2025-11-06
目的 总结儿童博卡病毒肺炎合并塑型性支气管炎的临床及影像学特征及预后。方法 回顾性分析2022年1月至2024年1月在我院确诊的13例博卡病毒肺炎合并塑型性支气管炎患儿的临床资料及随访结果。结果 共纳入13例患儿,男7例、女6例,中位年龄3.0(1.0~5.0)岁,其中≥3岁8例(61.54%),夏季入院8例(61.54%)。所有患儿均有发热、咳嗽,7例(53.85%)伴有喘息,3例有气促,平均热程(3.92±1.26)天,热峰(39.24±0.40)℃。1例合并中毒性脑病,1例有多形红斑,余无其他脏器功能损害。9例C反应蛋白(CRP)轻度升高,降钙素原(PCT)、乳酸脱氢酶(LDH)轻度升高。胸部CT以炎性实变为主,9例(69.23%)伴有肺不张,4例(30.77%)有少量胸腔积液,肺泡灌洗液细胞分型显示嗜酸细胞比例明显增高。所有患儿均行支气管镜下塑型物取出术,均好转出院,中位住院时间5.0(4.5~6.5)天。随访中1例出现反复喘息,后诊断为哮喘,余预后良好。结论 博卡病毒肺炎合并塑型性支气管炎夏季多见,多以高热起病,伴咳嗽喘息,CRP、PCT、LDH无显著升高,影像学以实变、肺不张为主,病程相对较短,不易合并严重的其他脏器功能损害,预后良好。
高微微 , 邹映雪 , 郭永盛 , 郭润 . 13例儿童博卡病毒肺炎合并塑型性支气管炎的临床与影像特点[J]. 临床儿科杂志, 2025 , 43(11) : 860 -865 . DOI: 10.12372/jcp.2025.25e0551
Objective To characterize the clinical and radiological features and prognosis of children with bocavirus pneumonia complicated by plastic bronchitis. Methods A retrospective analysis was conducted on the clinical data and follow-up results of 13 children diagnosed with bocavirus pneumonia complicated with plastic bronchitis in our hospital from January 2022 to January 2024. Results A total of 13 cases were included, including 7 males and 6 females, with a median age of 3.0 (1.0-5.0) years. Eight cases (61.5%) were hospitalized during summer. All patients presented with fever and cough; 7 (53.8%) had wheezing, and 3 exhibited tachypnea. The mean duration of fever was 3.92±1.26 days, with a peak temperature of 39.24±0.40 °C. Extrapolmonary complications included one case of toxic encephalopathy and one of erythema multiforme; no other organ dysfunction was observed. Laboratory findings revealed mild elevations in C-reactive protein (CRP) in 9 patients, with PCT and LDH were slightly elevated. Chest CT predominantly showed inflammatory consolidation, with atelectasis in 9 cases (69.2%) and small pleural effusions in 4 (30.8%). Bronchoalveolar lavage fluid analysis demonstrated marked eosinophilia. All patients underwent bronchoscopic removal of intraluminal casts and improved clinically, with a median hospital stay of 5.0 (4.5-6.5) days. During follow-up, one child developed recurrent wheezing and was subsequently diagnosed with asthma; the remaining patients had favorable outcomes. Conclusion Bocavirus pneumonia complicated by plastic bronchitis in children are more frequently observed during the summer months. The disease commonly presents with high fever, cough, and wheezing, with minimal elevation in inflammatory markers such as CRP, PCT, and LDH. Radiologically, consolidation and atelectasis are the predominant findings. The disease course is relatively short, and severe multi-organ involvement is uncommon. Overall, the prognosis is favorable.
Key words: plastic bronchitis; human bocavirus; medical imaging; child
| [1] | 中华人民共和国国家健康委员会, 国家中医药局. 儿童社区获得性肺炎诊疗规范(2019年版)[J]. 中华临床感染病杂志, 2019, 12(1): 6-13. |
| National Health Commission of the People's Republic of China, State Administration of Traditional Chinese Medicine. Guideline for diagnosis and treatment of community-acquired pneumonia in children (2019 version)[J]. Zhonghua Linchuang Ganranbing Zazhi, 2019, 12(1): 6-13. | |
| [2] | Gerna G, Piralla A, Rovida F, et al. Correlation of rhinovirus load in the respiratory tract and clinical symptoms in hospitalized immunocompetent and immunocompromised patients[J]. J Med Virol, 2009, 81(8): 1498-1507. |
| [3] | Allander T, Tammi MT, Eriksson M, et al. Cloning of a human parvovirus by molecular screening of respiratory tract samples[J]. Proc Natl Acad Sci USA, 2005, 102(36): 12891-12896. |
| [4] | Schildgen O, Müller A, Allander T, et al. Human bocavirus: passenger or pathogen in acute respiratory tract infections?[J]. Clin Microbiol Rev, 2008, 21(2): 291-304. |
| [5] | Christensen A, Nordb? SA, Krokstad S, et al. Human bocavirus in children: mono-detection, high viral load and viraemia are associated with respiratory tract infection[J]. J Clin Virol, 2010, 49(3): 158-162. |
| [6] | Jartti T, Hedman K, Jartti L, et al. Human bocavirus-the first 5 years[J]. Rev Med Virol, 2012, 22(1): 46-64. |
| [7] | Tan J, Huang Z, Tang W, et al. Human bocavirus-1 infection in hospitalized pediatric patients with acute respiratory tract infections[J]. Microbiol Spectr, 2025, 13(4): e0298524. |
| [8] | 刘霜君, 霍枫, 刘珺, 等. 需机械通气的儿童重症博卡病毒肺炎十例临床分析[J]. 中国小儿急救医学, 2024, 31(6): 449-454. |
| Liu SJ, Huo F, Liu J, et al. Retrospective analysis of ten patients with severe human Boca virus pneumonia required mechanical ventilation[J]. Zhongguo Xiaoer Jijiu Yixue, 2024, 31(6): 449-454. | |
| [9] | 陆秋蒙, 李莉. 博卡病毒感染引起塑形性支气管炎5例临床分析[J]. 中国医师杂志, 2022, 24(4): 613-615. |
| Lu QM, Li L. Clinical analysis of 5 cases of plastic bronchitis caused by Bocavirus infection[J]. Zhongguo Yishi Zazhi, 2022, 24(4): 613-615. | |
| [10] | 翟宇, 段素霞, 贾凡平, 等. 儿童呼吸道博卡病毒感染流行特征分析: 一项单中心回顾性研究[J]. 临床儿科杂志, 2025, 43(3): 184-190. |
| Zhai Y, Duan SX, Jia FP, et al. Analysis of epidemiological characteristics of respiratory tract Bocavirus infection in children: a single-center retrospective study[J]. Linchuang Erke Zazhi, 2025, 43(3): 184-190. | |
| [11] | An TJ, Lee J, Shin M, et al. Seasonality of common respiratory viruses: analysis of nationwide time-series data[J]. Respirology, 2024, 29(11): 985-993. |
| [12] | Sun Y, Jiang L, Chen Y, et al. Prevalence and molecular characterization of human bocavirus-1 in children and adults with influenza-like illness from Kunming, Southwest China[J]. Microbiol Spectr, 2025, 13(1): e0156424. |
| [13] | 高微微, 翟嘉, 郭永盛, 等. 11例儿童腺病毒肺炎合并塑型性支气管炎特征分析[J]. 临床儿科杂志, 2024, 42(6): 509-514. |
| Gao WW, Zhai J, Guo YS, et al. Clinical features of adenovirus pneumonia complicated with plastic bronchitis in 11 children[J]. Linchuang Erke Zazhi, 2024, 42(6): 509-514. | |
| [14] | 张蕾, 闫智慧, 王亚坤, 等. 儿童甲型H1N1流感合并塑型性支气管炎4例临床分析[J]. 浙江医学, 2022, 44(10): 1114-1115. |
| Zhang L, Yan ZH, Wang YK, et al. Clinical analysis of 4 pediatric cases of Influenza A (H1N1) complicated with plastic bronchitis[J]. Zhejiang Yixue, 2022, 44(10): 1114-1115. | |
| [15] | Wang W, Guan R, Liu Z, et al. Epidemiologic and clinical characteristics of human bocavirus infection in children hospitalized for acute respiratory tract infection in Qingdao, China[J]. Front Microbiol, 2022, 13: 935688. |
| [16] | Seyrek BE, Aykac K, Temizel ?S, et al. Bocavirus infection as a potential trigger for hepatic injury in children[J]. J Viral Hepat, 2025, 32(3): e70013. |
| [17] | Vallet C, Pons-Catalano C, Mandelcwajg A, et al. Human bocavirus: a cause of severe asthma exacerbation in children[J]. J Pediatr, 2009, 155(2): 286-288. |
| [18] | Del Rosal T, García-García ML, Calvo C, et al. Recurrent wheezing and asthma after bocavirus bronchiolitis[J]. Allergol Immunopathol (Madr), 2016, 44(5): 410-414. |
| [19] | Yabushita H, Otake S, Iida S, et al. Plastic bronchitis of human Bocavirus 1 detected by comprehensive polymerase chain reaction of mucus casts[J]. Jpn J Infect Dis, 2023, 76(2): 155-158. |
| [20] | Fei-Zhou Z, Mei-Xia H, Xiaofen T, et al. Plastic bronchitis associated with human bocavirus 1 infection in children[J]. Pediatr Pulmonol, 2024, 59(11): 2754-2760. |
| [21] | Zhang X, Zhao J. Plastic bronchitis linked to human bocavirus 1 identified through high-throughput next-generation sequencing: a case report[J]. Medicine (Baltimore), 2024, 103(36): e39361. |
| [22] | Chiang SR, Lin CY, Chen DY, et al. The effects of human parvovirus VP1 unique region in a mouse model of allergic asthma[J]. PLoS One, 2019, 14(5): e0216799. |
| [23] | Fukuchi M, Miyabe Y, Furutani C, et al. How to detect eosinophil ETosis (EETosis) and extracellular traps[J]. Allergol Int, 2021, 70(1): 19-29. |
| [24] | Yoshida M, Miyahara Y, Orimo K, et al. Eosinophil extracellular traps in the casts of plastic bronchitis associated with influenza virus infection[J]. Chest, 2021, 160(3): 854-857. |
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