患儿系G1P1，胎龄38周，出生体重3.1 kg，Apgar评分10分。患儿生后头顶部即有一枚淡蓝色结节，当地医院考虑为“血管瘤”。患儿后期皮肤类似结节逐渐增多。2.5月龄时，患儿就诊我院皮肤科。查体：神志清，精神反应可，未见“浣熊眼”体征。全身皮肤散在蚕豆大小淡蓝色结节，质地韧，表面光滑，移动性欠佳，无触痛，考虑占位性病变可能，予以皮损B超及肝脾B超检查提示肝脏多发占位性病变，转诊至肿瘤科，最终病理确诊为神经母细胞瘤，并予以化疗联合手术治疗，目前诊后随访10年，患儿体健。新生儿起病的皮肤单发淡蓝色肿物，需要触诊检查肿物质地，如质地韧，及时转诊肿瘤外科筛查神经母细胞瘤的可能。

The patient was a G1P1 neonate born at 38 weeks of gestation with a birth weight of 3.1 kg and an Apgar score of 10. A pale blue nodule was noted on the vertex of the infant’s head immediately after birth, which was misdiagnosed as a hemangioma at a local hospital. Subsequently, similar cutaneous nodules gradually appeared on skin, and the infant was admitted to the Department of Dermatology of our hospital at the age of 2.5 months. Physical examination showed that no raccoon eyes sign was observed. Multiple pale blue nodules, the size of broad beans, were scattered on the skin firm in texture, smooth in surface, with poor mobility and no tenderness. Skin lesion ultrasound and hepatosplenic ultrasound revealed multiple lesions in the liver, and the infant was then referred to the Department of Oncology. Neuroblastoma was finally confirmed by pathological examination. The infant received chemotherapy combined with surgical treatment, and has been well who was followed up for 10 years after diagnosis. For single pale blue cutaneous nodule in the neonatal period, palpation to evaluate the texture of the nodule is necessary. Firm nodule may indicate the need for timely referral to surgical oncology for screening of neuroblastoma.