目的　探讨重症肺炎患儿血清N末端脑钠素原(NT-ProBNP)和肌钙蛋白I(cTnI)水平的变化及其临床价值。方法　重症肺炎患儿72例，分为重症肺炎无心力衰竭(HF)组(56例)与重症肺炎合并HF组(16例)；另选择30例健康儿童作为正常对照组。检测并比较各组血清NT-ProBNP和cTnI水平。 结果　三组间NT-ProBNP和cTnI水平差异有统计学意义(P均=0.000)。重症肺炎无HF组与合并HF组的NT-ProBNP和cTnI水平高于对照组；重症肺炎合并HF组血清NT-ProBNP及cTnI水平高于重症肺炎无HF组，差异有统计学意义(P均<0.01)。重症肺炎患儿中，合并HF组的cTnI异常率明显高于无HF组，差异有统计学意义(P=0.037)，而二组的NT-ProBNP异常率差异无统计学意义(P=0.375)；重症肺炎患儿的NTProBNP与cTnI水平呈显著正相关(r=0.85，P=0.000)。 结论　重症肺炎患儿心肌损害明显，NT-ProBNP、cTnI可作为辅助诊断儿童重症肺炎心肌损害及严重程度的重要血清学标志物。

Objective To study the clinical value of serum N-terminal pro-brain natriuretic peptide (NT-ProBNP) and cardiac troponin I (cTnI) levels in children with severe pneumonia. Methods A total of 72 children with severe pneumonia in pediatric intensive care unit were divided into heart failure (HF) group and non-HF group according to the occurrence of heart failure, and 30 healthy children were selected as control group. Serum NT-ProBNP and cTnI levels were detected and analyzed. Results Compared with control group, NT-ProBNP and cTnI levels were significantly higher (P<0.01) in HF and non-HF group. The levels of NT-ProBNP and cTnI in HFgroup were both significantly higher (P<0.01) than that in non-HFgroup. Serum NTProBNP level was positively related to the level of cTnI(P=0.000) in children with severe pneumonia. The abnormal rate of cTnI in HF group was significantly higher (P=0.037) than that in non-HFgroup. The difference of the abnormal rate of NTProBNP between the two groups was not significant (P=0.375), however, the abnormal rate of NT-ProBNP was significantly higher (P=0.036) than that of cTnI in non-HF group. Conclusions There was obvious myocardial damage in children with severe pneumonia. NT-ProBNP and cTnI could be important serological markers to assist diagnosis of myocardial damage and its severity.