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CD40基因多态性与川崎病及其临床特点的相关性分析

  • 张超 ,
  • 李月茹 ,
  • 董启忠
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  • 湖北省江汉油田总医院儿科(湖北潜江 433124)

收稿日期: 2014-08-15

  网络出版日期: 2014-08-15

Association between polymorphism of CD40 gene and clinical characteristics in Kawasaki disease

  • ZHANG Chao ,
  • LI Yueru ,
  • DONG Qizhang
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  • Department of Pediatrics, Hubei Jianghan Oilfield General Hospital, Qianjiang 433124, Hubei, China

Received date: 2014-08-15

  Online published: 2014-08-15

摘要

目的 探讨CD40基因的SNP位点rs1569723多态性与川崎病(KD)以及临床特点的相关性。方法 采取病例对照研究方法,分别选取179例KD患儿和197例健康儿童作为研究对象。利用PCR-RFLP的方法测定SNP位点多态性分布;超声心动图检测动脉损伤。结果 KD组的SNP位点(rs1569723)的3种基因型(AA、AC、CC)分布与对照组相比,差异有统计学意义(P=0.044),且A风险等位基因与KD易感性显著相关(OR=1.51,95%CI:1.10-2.07,P=0.012)。SNP位点(rs1569723)3种基因型(AA、AC、CC),皮疹及淋巴结肿大的发生概率均以AA基因型的发生概率为最高,CC基因型最低,差异均有统计学意义(P=0.041、0.010)。SNP位点(rs1569723)多态性与结膜充血、口腔黏膜病变、手足水肿、冠状动脉损伤无关(P均>0.05)。结论 CD40基因SNP位点(rs1569723)与KD的易感性相关,A等位基因为风险因子;且该SNP位点可能与KD患儿的皮疹以及淋巴结肿大等特征相关。

本文引用格式

张超 , 李月茹 , 董启忠 . CD40基因多态性与川崎病及其临床特点的相关性分析[J]. 临床儿科杂志, 2014 , 32(8) : 760 . DOI: 10.3969 j.issn.1000-3606.2014.08.016

Abstract

Objective To investigate the association between nucleotide polymorphisms (rs1569723 in CD40 gene) and clinical characteristics in Kawasaki disease (KD) in Han Chinese children. Methods A case-control study was performed,and 179 children with KD and other 197 normal children served as controls were included. The SNP genotypes were detected using PCR-RFLP, and all data were analyzed by SPSS 19.0. Results It was found that the SNP (rs1569723) was associated with KD (P=0.048), and the frequency of A allele in KD group was higher than that in control group (OR=1.505, 95%CI:1.095-2.070, P=0.012). SNP genotypes were associated with rash and lymphadenopathy (P=0.041, 0.047), but not associated with conjunctival hyperemia, hand-foot edema, oral mucosa lesions, and coronary artery lesion (P=0.688,0.758, 0.557, 0.552). Conclusions Genotypes of SNP (rs1569723) were associated with KD susceptibility, and A-allele is a risk allele. The SNP loci might be associated with rash and lymphadenopathy in KD in Han Chinese.
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