自噬是细胞利用溶酶体降解自身受损的细胞器和大分子物质的过程，是广泛存在于自然界中的一种生命现象，对于维持细胞结构及功能的稳定性起着重要的作用。研究表明，参与多个生理及病理过程的PI3K/Akt信号通路是影响细胞自噬的重要信号通路之一。近年来研究发现，肾小球足细胞自噬活性水平以及足细胞病的产生都与PI3K/Akt信号通路存在密切关系。文章主要介绍肾小球足细胞自噬与PI3K/Akt信号通路的关系。

Autophagy is the process that cells degradate the damaged organelles and the macromolecules by lysosomes. It is a phenomenon of life which is widely existed in nature and plays an important role in maintaining the stability of cellular structure. Current studies showed that the PI3K/Akt signaling pathway, which involved in multiple physiological and pathological processes, is one of the important signaling pathways of autophagy. Recent studies found that the levels of podocyte autophagy and the podocyte diseases have close relationship with PI3K/Akt signaling pathway. In this article, the relationship between autophagy and the PI3K/Akt pathway will be reviewed.