目的 探讨病毒性脑炎（VE）患儿血清和脑脊液中半乳糖凝集素-9（Gal-9）的变化，及其对疾病的诊断、判断预后的指 导意义。 方法 采用双抗体夹心酶联免疫吸附法检测VE患儿急性期、恢复期以及对照组血清和脑脊液中Gal-9的水平，并进行比 较。 结果 VE患儿急性期、恢复期以及对照组患儿进行比较，三组的血清和脑脊液中Gal-9水平的差异均有统计学意义（F = 92.60、 81.90， P ＜ 0.01）。 其中，VE患儿急性期、恢复期的血清和脑脊液中Gal-9水平均高于对照组，差异有统计学意义（P ＜ 0.01）；VE 恢复期的血清和脑脊液中Gal-9水平均高于急性期，差异有统计学意义（P ＜ 0.01）。VE和对照组全体患儿血清中Gal-9水平与脑 脊液中Gal-9水平呈正相关（r = 0.523， P ＜?0.01）。VE患儿脑脊液中Gal-9水平与有核细胞数呈负相关（rs = －0.469， P ＜ 0.001）。 结论 Gal-9可能参与VE的发病过程。

Objective To investigate the changes of Galectin-9 (Gal-9) in serum and cerebrospinal fluid in children with viral encephalitis (VE) and to epxplore its potential significance in the diagnosis and prognosis of VE. Methods The levels of Gal-9 in serum and cerebrospinal fluid were detected by enzyme-linked immunosorbent assay double-antibody sandwich and compared in 30children with VE in acute and convalescent phases and in 12 children without VE. Results The differences of Gal-9 levels in serum and cerebrospinal fluid were statistically significant between VE acute phase group and VE recovery phase group as well as control group (F = 92.70, 81.95, P < 0.01). The Gal-9 levels in serum and cerebrospinal fluid of the children in VE acute phase and of the children in VE recovery phase were significantly higher compared to those in the control group (P < 0.01). The levels of Gal-9 in serum and cerebrospinal fluid of children in VE convalescent phase are significantly higher than those in acute phase of VE (P < 0.01). There was a positive correlation between levels of Gal9 in cerebrospinal fluid and in serum (r =0.523, P < 0.01). The levels of SP-D correlated negatively with the total CSF leucocytic count in children of VE (rs= -0.469, P < 0.001). Conclusions Gal-9 played an important role in the later stage of viral encephalitis recovery.