目的　探讨血清白介素-1β（ IL-1β）及白介素-6（IL-6）在儿童高尿酸血症（HUA）发病中的作用及意义。 方法　选择HUA患儿71例，按是否有关节红肿热痛及活动障碍病史分为有关节症状组（GA组， n=28）及无关节症状 组（NGA组， n=43）；同时选取71例健康体检儿童和腹股沟斜疝修补术患儿为对照组。采用双抗体夹心酶联免疫吸附法 （ELISA）检测所有患儿血清IL-1β、IL-6水平。结果　HUA组患儿血清IL-1β、IL-6浓度高于正常对照组，差异均有统 计学意义（P均<0.05）；GA组急性期血清IL-1β、IL-6浓度高于缓解期、NGA组及正常对照组，GA组缓解期和NGA组 血清IL-1β、IL-6浓度高于正常对照组，差异均有统计学意义（P均<0.05）。 患儿血清IL-1β、IL-6浓度与血白细胞计数、 中性粒细胞、单核细胞、血尿酸、血沉、 C反应蛋白、尿素氮、肌酐水平呈显著正相关（P均<0.05） )，与血三酰甘油、总胆固 醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇水平无相关性（P均>0.05）。 结论　IL-1β、IL-6在HUA患儿的炎症反应 机制中发挥重要作用。

　Objective　To explore the significance of interleukin (IL)-1β and IL-6 in serum of children with hyperuricemia (HUA). Methods　142 children including 71 children with HUA (HUA group) and 71 control children (control group), healthy  and inguinal hernia children were selected as control group. 71 HUA children were subdivided into GA (gout attacks) group (n=28) and NGA (non-gout attacks) group (n=43) according to whether they had a history of acute gout attacks, including sudden monoarthritis of rapid onset with intense pain and swelling or without. Enzyme-linked immunosorbent assay was used to measure the level of IL-1β and IL-6 in serum. Results Serum IL-1β and IL-6 levels of HUA children were significantly higher than those of control group (all P<0.05). Serum IL-1β and IL-6 levels of HUA children in GA group were significantly higher than those of NGA group (P<0.05). Serum IL-1β and IL-6 levels of GA group in acute phase was significantly higher than those of HUA children in remission stage、NGA group and control group (P<0.05). Serum IL-1β and IL-6 levels of GA group in remission stage and NGA group was significantly higher than those of control group (P<0.05). There were no significant differences between HUA children in remission stage and NGA group (P>0.05). The serum IL-1β and IL-6 levels of HUA children were positively correlated with WBC, neutrophils, monocytes, uric acid, ESR, CRP, BUN and Cr (all P<0.05), while not correlated with triglyceride, total cholesterol, LDL-C and HDL-C(all P<0.05). Conclusion IL-1β and IL-6 play an important role in the pathogenesis of HUA in children.