Abstract: Objectives To summarize the clinical characteristics of granulomatous periorificial dermatitis in children and to observe the efficacy of clarithromycin in the treatment of granulomatous periorificial dermatitis in children.Methods The clinical data of 6 children with granulomatous periorificial dermatitis treated with clarithromycin from December 2018 to March 2021 were retrospectively analyzed and the relevant literature was reviewed.Results Six children (2 boys and 4 girls) with granulomatous periorificial dermatitis were enrolled, and the median age was 5.0 (4.3-5.0) years. The skin lesions were characterized by erythematous papules involving the perioral and perinasal areas in all 6 cases. In addition, 3 cases involved the periocular area, 1 case involved the neck, and 1 case involved the vulva. The median course of the disease was 4.0 (3.3-7.8) months. After diagnosis, 125 mg clarithromycin was given orally, once a day. The median time of skin lesion clearance was 18.0(16.0-19.0) weeks. During the follow-up, no adverse effect was observed. Conclusion Clarithromycin may be effective and safe in the treatment of granulomatous periorificial dermatitis in children.

Key words: granulomatous periorificial dermatitis, clarithromycin, treatment, child