儿童再生障碍性贫血造血干细胞移植相关并发症

doi:10.12372/jcp.2022.22e1706

Abstract

Abstract:

Aplastic anemia (AA) is a bone marrow hematopoietic failure disorder that is characterized by low bone marrow hematopoiesis, complete blood cytopenia and anemia/hemorrhage/infection syndrome. Allogeneic hematopoietic stem cell transplantation is currently an important method in the treatment of severe AA. The occurrence and management of transplant-related complications remain a great clinical challenge, and their prevention and treatment can directly affect the outcome of transplantation, long-term survival and quality of life of the children. In this paper, we review the diagnosis, prevention and treatment of common transplant complications during HSCT in children with AA, with the aim of improving the success rate and survival rate of these transplanted children.

Key words: aplastic anemia, allogeneic hematopoietic stem cell transplantation, complication, child

XU Jiawei, JIN Runming. Research progress in complications related to hematopoietic stem cell transplantation in children with aplastic anemia[J].Journal of Clinical Pediatrics, 2023, 41(3): 175-180.

Figures/Tables 1

References 41

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Research progress in complications related to hematopoietic stem cell transplantation in children with aplastic anemia

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组织活检有微血栓证据或满足以下7项指标中的5项
①乳酸脱氢酶（LDH）超过正常值上限
②蛋白尿（随机尿蛋白超过正常值上限或随机尿蛋白/肌酐≥2mg/mg
③高血压（年龄<18岁：血压高于同年龄、性别和身高的健康人群血压正常参考值的上限；年龄≥18岁：血压≥140/90mmHg）
④新发的血小板减少（血小板计数<50×10⁹/L或血小板计数较基线水平减少≥50%
⑤新发的贫血（血红蛋白值低于正常参考值下限或输血需求增加）
⑥微血管病变证据（外周血中存在破碎红细胞或组织标本病理学检查结果提示微血管病）
⑦终末补体活化（血浆sC5b-9值高于健康人群正常值上限）