Journal of Clinical Pediatrics ›› 2024, Vol. 42 ›› Issue (2): 139-145.doi: 10.12372/jcp.2024.22e1533
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SUN Ruonan, LI Bohan, ZHENG Defei, ZHAO Xiaying, LIN Ziyun, HU Yixin, GAO Li, GAO Jing, LI Jie, LU Jun, XIAO Peifang, PAN Jian, LING Jing, FANG Fang, HU Shaoyan()
Received:
2022-11-17
Online:
2024-02-15
Published:
2024-02-02
SUN Ruonan, LI Bohan, ZHENG Defei, ZHAO Xiaying, LIN Ziyun, HU Yixin, GAO Li, GAO Jing, LI Jie, LU Jun, XIAO Peifang, PAN Jian, LING Jing, FANG Fang, HU Shaoyan. Factors related to bronchiolitis obliterans syndrome in pediatric patients survived longer than 100 days after hematopoietic stem cell transplantation[J].Journal of Clinical Pediatrics, 2024, 42(2): 139-145.
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项 目 | Non-BOS组(n=322) | BOS组(n=29) | 统计量 | P |
---|---|---|---|---|
年龄[M(P25~P75)]/月 | 75.0(38.0~119.0) | 92.0(67.0~132.0) | Z=2.18 | 0.029 |
男性[n(%)] | 202(62.7) | 11(37.9) | χ2=8.88 | 0.009 |
ABO血型相合[n(%)] | 159(49.4) | 14(48.3) | χ2=0.01 | 0.909 |
疾病为恶性疾病[n(%)] | 208(64.6) | 22(75.9) | χ2=1.73 | 0.221 |
供体类型[n(%)] | χ2=2.05 | 0.613 | ||
脐带血移植 | 97(30.1) | 8(27.6) | ||
单倍体移植 | 145(45) | 11(37.9) | ||
同胞全相合移植 | 42(13) | 4(13.8) | ||
无关供体移植 | 38(11.8) | 6(20.7) | ||
干细胞来源[n(%)] | χ2=4.80 | 0.230 | ||
脐带血 | 97(30.1) | 8(27.6) | ||
骨髓 | 15(4.7) | 0 | ||
外周血 | 62(19.3) | 10(34.5) | ||
外周血+骨髓 | 148(46.0) | 11(37.9) | ||
预处理方案[n(%)] | χ2=0.40 | 0.530 | ||
清髓预处理 | 147(45.7) | 15(51.7) | ||
减低剂量预处理 | 175(54.3) | 14(48.3) | ||
预处理方案中有全身照射[n(%)] | 29(9.0) | 1(3.4) | - | 0.4921) |
预处理方案中有白消安[n(%)] | 264(82.0) | 27(93.1) | - | 0.1951) |
预处理方案中有ATG[n(%)] | 161(50.0) | 14(48.3) | χ2=0.03 | 0.859 |
发生BOS前有CMV血症[n(%)] | 212(65.8) | 22(75.9) | χ2=1.20 | 0.273 |
发生BOS前有细小病毒血症[n(%)] | 87(27.0) | 12(41.4) | χ2=2.71 | 0.100 |
移植后100天内有呼吸系统疾病[n(%)] | 84(26.1) | 16(55.2) | χ2=17.87 | 0.001 |
aGVHD[n(%)] | χ2=0.00 | 0.947 | ||
0 ~Ⅰ度 | 235(73.0) | 21(72.4) | ||
Ⅱ~Ⅳ度 | 87(27.0) | 8(27.6) | ||
合并其他靶器官cGVHD[n(%)] | 115(35.7) | 28(96.6) | χ2=36.37 | <0.001 |
总单个核细胞数[M(P25~P75)]/×108·kg-1 | 7.9(2.0~12.1) | 4.1(3.2~12.3) | Z=0.29 | 0.880 |
总CD34+细胞数[M(P25~P75)]/×106·kg-1 | 7.4(3.2~7.0) | 4.1(2.4~9.0) | Z=0.77 | 0.397 |
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