Abstract: Objective To investigate the association between single nucleotide polymorphisms (SNP) rs 653765 and rs 514049 in ADAM10 gene and clinical characteristics in asthma in Han Chinese children. Methods A case-control study was performed in that research, and 221 children with asthma were recruited and an other 236 normal children were recruited as controls. The genotypes of two SNPs in ADAM10 gene were detected using PCR-RFLP. And all data were analyzed by SPSS19 . 0 . Results In case-controlled study, we found the frequency of TT genotype in case group was higher than that of controlgroup (P = 0 . 028 ), and the frequency of T allele was higher than that of control group (P = 0 . 008 ). The genotypes and alleles of rs 514049 was not associated with asthma (P = 0 . 604 , 0 . 356 ).There were no difference in serum ADAM 10 levels between asthma and control group (P = 0 . 238 ), but in asthma group we found patients with TT genotype may have a higher level ADAM 10 than the one with CC genotype (P = 0 . 034 ). The polymorphism of rs 653765 was not associated with the level of C-reaction protein, the number of LYM, IgE and EOS% (P > 0 . 05 ). Conclusions The genotype of rs 653765 in ADAM10 gene was associated with asthma in the central of China, and T allele was a risk factor. The polymorphism of rs 653765 might be associated with the levels of ADAM 10 .