Abstract: Objective To evaluate the value of echocardiography in the diagnosis of congenital heart disease (CHD) complicated with infective endocarditis (IE). Methods　The clinical data of CHD children with IE diagnosed in hospital from January 2009 to July 2018 were retrospectively analyzed. Results　A total of 42 CHD children (20 males and 22 females) complicated with IE were enrolled. The median age of the children was 7 years and 1 month. Among them 17 (40.5%) were the school-age children, followed by 15 infants (35.7%). Twenty-seven (27) cases were preoperative, CHD including 19 cases of leftto-right high-speed shunt CHD (70.4%) and 15 cases of post-operative CHD. The main types of CHD were ventricular septal defect in 19 cases (45.2%) and complex CHD in 10 cases (23.8%). The clinical manifestations were fever in 37 cases (88.1%) and positive blood culture in 18 cases (43.9%). Ultrasound showed that there were 24 cases of vegetations, 16 cases (38.1%) before operation, 8 cases (19.0%) after operation, and 1 case of left endocardial thickening with echo enhancement before operation. The total positive rate was 59.5%. A total of 38 vegetations were found, most commonly located at the valve 22. In the preoperative group, 11 patients received surgical treatment, and 10 patients were confirmed with vegetations (another 1 patient was examined with vegetations continuously shrinking before surgery), 5 cases (45.5%) of valve-related injuries were found during operation. The remaining 3 cases were transferred to another hospital for further treatment, but 2 cases did not recover. In postoperative group, 5 cases were found to have reduced or disappeared vegetations, 2 cases were transferred to another hospital for further treatment and 1 case was not cured. Among the complications associated with ultrasound, 3 patients had pericardial effusion and 1 patient had peripheral vascular embolization, before operation. 16 children with clinical vegetation were treated effectively, and 15 children with no vegetation were treated effectively, the total effective treatment rate was 73.8%. Conclusion　Ultrasound can provide an effective basis for the diagnosis of children with CHD complicated with IE. It can also provide great clinical value in assessing the development of the disease and prognosis.

Key words: congenital heart disease;　infectious endocarditis;　ultrasound;　child