Journal of Clinical Pediatrics ›› 2023, Vol. 41 ›› Issue (5): 387-393.doi: 10.12372/jcp.2023.22e1064

• Literature Review • Previous Articles     Next Articles

Advances in the study of bedaquiline and delamanid in the treatment of drug-resistant tuberculosis in children

Reviewer: WANG Xiyu, Reviser: XU Hongmei   

  1. Department of Infection Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400010, China
  • Received:2022-08-08 Online:2023-05-15 Published:2023-05-10

Abstract:

Tuberculosis (TB) is one of the major global public health concerns, and drug-resistant TB is one of the major obstacles to achieve the goal of ending TB due to the long treatment period, complicated regimens, multiple adverse effects and poor efficacy. In recent years, bedaquiline and delamanid have gradually become promising new drugs, but there is lack of researches on the application of these drugs in children with drug-resistant tuberculosis in China. This article reviews the efficacy and safety of bedaquiline and delamanid in drug-resistant tuberculosis and the progress of their use in children, in order to help construct new and effective regimens for the treatment of drug-resistant tuberculosis in children.

Key words: tuberculosis, drug-resistant tuberculosis, bedaquiline, delamanid, child