Journal of Clinical Pediatrics ›› 2025, Vol. 43 ›› Issue (10): 762-767.doi: 10.12372/jcp.2025.25e0216

• Original Article • Previous Articles     Next Articles

Analysis of clinical characteristics and prognostic factors of 45 children with hemophagocytic syndrome

JIANG Wenxuan, YE Fanghua, XIAO Yixin, YANG Liangchun()   

  1. Xiangya Hospital, Central South University, Changsha 410008, Hunan, China
  • Received:2023-10-17 Accepted:2024-10-16 Published:2025-10-15 Online:2025-09-29
  • Contact: YANG Liangchun E-mail:405010@csu.edu.cn

Abstract:

Objective To analyze the clinical characteristics and prognostic factors of hemophagocytic syndrome (HPS) in children. Methods A retrospective analysis was conducted on the clinical data and follow-up information of 45 children with HPS admitted from January 2017 to July 2023. Results The median age of onset in the 45 children was 4.5 (2.1-10.0) years, all of whom started with fever. Infection-related HPS accounted for 77.8%, with Epstein-Barr virus (EBV) infection being the most common (85.7%). The overall survival rate of all children was (88.9±4.7)%. Univariate analysis showed that triglycerides≥3.8 mmol/L and lactate dehydrogenase≥2500 U/L were risk factors affecting the prognosis of children with HPS (P<0.05 for both), and multivariate analysis showed that triglycerides≥3.8 mmol/L was an independent risk factor affecting the prognosis of children with HPS (P=0.029). Conclusion HPS often starts with fever, and infection (especially EBV infection) is the most common cause; the levels of triglycerides and lactate dehydrogenase at initial diagnosis (especially triglycerides≥3.8 mmol/L) are key factors in assessing prognosis.

Key words: hemophagocytic syndrome, clinical characteristics, treatment, prognosis, child

CLC Number: 

  • R72