儿童听觉事件相关电位正常参考值构建的初步探索

doi:10.12372/jcp.2025.25e0814

Abstract

Abstract:

Objective To establish a range of clinical reference values for each component of P1, N1, P2, N2, and P3 in auditory event related potentials (AERPs) in normal children aged 6-17 years, and to provide an assessment of cognitive impairments caused by clinically relevant diseases in children. Methods Healthy children with normal hearing who visited the Diagnosis and Treatment Center for Hearing Impairment and Vertigo between January 2024 and January 2025 were selected as study participants. AERPs were recorded using the auditory Oddball paradigm. Differences in AERP waveform components between both ears were compared, and normative values for the latency and amplitude of each AERP component were established. Results A total of 28 healthy children (56 ears) with normal hearing aged 6 to 17 years were included, with an average age of (8.75±2.40) years, including 15 boys (30 ears) and 13 girls (26 ears). The normal latency of each wave component of AERP in children is as follows: P1 (56.00±13.11) ms, N1 (106.36±15.26) ms, P2 (183.29±26.77) ms, N2 (229.21±26.28) ms and P3 (329.89±22.32) ms. The 95% confidence intervals (CI) are: P1 (30.29-81.71) ms, N1 (76.44-136.27) ms, P2 (130.82-235.75) ms, N2 (177.71-280.72) ms, and P3 (286.14-373.64) ms. The amplitude values are as follows: P1 [6.91 (4.91 - 10.92)] μV, P1-N1 [9.26 (4.82 - 14.79)] μV, N1-P2 [9.90 (5.60-14.25)] μV, P2-N2 [6.21 (4.40-9.94)] μV and N2-P3 [10.68 (5.95-15.81)] μV; 95% confidence intervals are: P1 (5.37-10.43) μV, P1-N1 (6.06-11.79) μV, N1-P2 (6.96-12.98) μV, P2-N2 (5.20-8.80) μV and N2-P3 (9.15-14.93) μV. Conclusions This study initially established the normal reference values of each component of AERPs for children aged 6 to 17, which is helpful in providing data support for the clinical assessment of cognitive function impairment in children.

Key words: auditory event-related potentials, normative reference value, cognitive function, child

CLC Number:

WEI Lin, SHEN Jiali, MA Xiaobao, WANG Wei, WANG Lu, JIN Yulian, YANG Jun, ZHENG Guiliang, LOU Gaozhong, ZHAO Zhehong, CHEN Jianyong. Preliminary exploration on establishment of normal reference value for auditory event related potentials in children[J].Journal of Clinical Pediatrics, 2025, 43(12): 915-921.

Figures/Tables 6

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References 27

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AERPs各成分	侧别	耳数	潜伏期($\bar{x}±s$)/ms	t值	P
P1	右	28	57.71±21.55	0.66	0.513
	左	28	54.29±15.95	0.66	0.513
N1	右	28	107.07±22.41	0.28	0.786
	左	28	105.64±18.52	0.28	0.786
P2	右	28	186.93±31.35	1.26	0.219
	左	28	179.64±30.31	1.26	0.219
N2	右	28	229.64±33.16	0.14	0.889
	左	28	228.79±28.32	0.14	0.889
P3	右	28	327.71±20.40	1.07	0.294
	左	28	332.07±28.50	1.07	0.294

AERPs各成分	侧别	耳数	振幅[M(P₂₅~P₇₅)]/μV	Z值	P
P1	右	28	8.41(4.5~11.97)	1.14	0.255
	左	28	6.45(2.6~11.99)	1.14	0.255
N1	右	28	7.68(4.39~12.86)	0.59	0.554
	左	28	8.49(4.15~14.12)	0.59	0.554
P2	右	28	9.03(3.59~16.05)	0.02	0.982
	左	28	9.31(4.61~16.93)	0.02	0.982
N2	右	28	6.06(2.78~10.48)	0.66	0.509
	左	28	6.87(3.91~13.55)	0.66	0.509
P3	右	28	9.70(4.13~19.26)	0.16	0.873
	左	28	9.66(5.23~16.13)	0.16	0.873

Preliminary exploration on establishment of normal reference value for auditory event related potentials in children

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