输血相关性坏死性小肠结肠炎的思考

doi:10.12372/jcp.2022.22e0361

Abstract

Abstract:

Neonatal necrotizing enterocolitis (NEC) is a serious and life-threatening gastrointestinal disease in the neonatal period. The atypical clinical manifestations of NEC, especially in premature infants, are abdominal distension, vomiting, bloody stools and shock. At present, the widely known pathogenesis of NEC includes preterm birth, infection, hypoxia-ischemia and improper feeding, etc. In recent years, the association between red blood cell transfusion (RBCT) and NEC was widely concerned. This article reviewed the relationship between RBCT and NEC, the influence factors, possible pathologic mechanism and the prevention strategies of transfusion-associated necrotizing enterocolitis (TANEC). Based on the available evidences, the author believes that TANEC is a clinical condition. However, anemia is the basis for the onset of TANEC. Prevention of anemia and reasonable blood transfusion are the basic strategies to reduce TANEC.

Key words: necrotizing enterocolitis, red blood cell transfusion, newborn

LEI Xiaoping, LUO Lijuan. Transfusion-associated necrotizing enterocolitis[J].Journal of Clinical Pediatrics, 2022, 40(9): 647-653.

Figures/Tables 2

References 53

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Transfusion-associated necrotizing enterocolitis

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出生日龄	严格输血阈值				宽松输血阈值
	危重		非危重		危重		非危重
	Hb/g·L^–1	Hct/％	Hb/g·L^–1	Hct/％	Hb/g·L^–1	Hct/％	Hb/g·L^–1	Hct/％
≤ 7 d	115	34	95	28	140	41	120	35
8~21 d	100	30	80	24	125	37	105	31
≥ 21 d	90	27	70	21	115	34	95	28

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