Presepsin在儿童脓毒症中的研究进展

doi:10.12372/jcp.2023.22e1144

Abstract

Abstract:

Sepsis, a life-threatening disease, is one of the main causes of morbidity and even death in pediatric patients. Early diagnosis and timely treatment can improve the patient survival rate. The application of blood culture, C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6) in the diagnosis of sepsis is a hot spot of current research, but its specificity and sensitivity are limited, and the detection time is too long. Soluble leukocyte differentiation antigen 14 subtype (sCD14-ST, or Presepsin) is a novel biomarker that not only has high specificity and sensitivity in the early diagnosis of sepsis in children, but also has certain value in evaluating the severity of sepsis, antimicrobial treatment and prognosis, and the detection method is fast and accurate. It has the feasibility of clinical application.This article reviews the evaluation of Presepsin in the diagnosis of sepsis, with a view to conducting more clinical studies to guide its application.

Key words: soluble leukocyte differentiation antigen 14 subtype, sepsis, child

LIU Jing, YANG Xinli, SHI Baohai, ZHANG Qingxiu. Research Progress of Presepsin in Children with Sepsis[J].Journal of Clinical Pediatrics, 2023, 41(11): 870-874.

References 40

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Research Progress of Presepsin in Children with Sepsis

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