关键词: 支气管肺发育不良；　MALAT1；　细胞凋亡诱导因子；　早产儿

Abstract: Objective　To observe long non-coding RNA MALAT1 and AIF expression in the peripheral venous blood of premature infants with bronchopulmonary dysplasia, and its relationship with BPD. Methods　Twenty cases of premature infants with bronchopulmonary dysplasia admitted to the Neonatology Department of Shanghai Children's Hospital from January 2015 to December 2016 were selected as BPD group, and 20 cases of premature infants whose oxygen inhalation time less than 3 days and gestational age less than 32 weeks were selected as control group. Clinical data of 40 cases of premature infants and the residual peripheral blood samples during physical examinations in this hospital were retrospectively analyzed, the expression levels of MALAT1 and AIF in serum were measured by real-time PCR. The data of two groups were compared by t test. Results (1) Compared with the control group, the expression of MALAT1 in peripheral blood of premature infants in BPD group were significantly increased [0.2734±0.0673 vs 0.3755±0.0819, P<0.05]. (2) Compared with the control group, the expression of AIF in peripheral blood of premature infants in BPD group were significantly decreased [0.0068±0.00196 vs 0.0045±0.00187, P<0.05]. Conclusion　The premature infants with BPD have abnormal expression of long non-coding RNA MALAT1 and AIF in the blood. Such abnormal changes may be involved in the pathogenesis of BPD.

Key words: 　bronchopulmonary dysplasia;　MALAT1;　apoptosis induced factor;　premature