临床儿科杂志 ›› 2021, Vol. 39 ›› Issue (10): 792-.doi: 10.3969/j.issn.1000-3606.2021.10.019

• 文献综述 • 上一篇    下一篇

类川崎病——儿童多系统炎症综合征诊疗相关研究现状

王亮综述, 沈永明审校   

  1. 天津市儿童医院检验科(天津 300074)
  • 出版日期:2021-10-15 发布日期:2021-09-28

Research progress for diagnosis and treatment of multisystem inflammatory syndrome in children

Reviewer: WANG Liang, Reviser: SHEN Yongming   

  1. Department of clinical laboratory, Tianjin Children's Hospital, Tianjin 300074, China
  • Online:2021-10-15 Published:2021-09-28

摘要: 儿童多系统炎症综合征(MIS-C)是一种类川崎病样表现的严重炎症综合征,可表现出中毒性休克和心源性 或血管麻痹性休克。MIS-C具有不典型的发病年龄(年龄偏大)和种族背景(非亚裔)。MIS-C病情危重,可短时间内快速进 展并恶化。由于存在严重急性呼吸综合征冠状病毒2(SARS-CoV- 2)感染的证据(RT-PCR或者血清学检测),MIS-C的发 生与SARS-CoV- 2有潜在联系。MIS-C的发病机制尚不清楚,目前主要沿用川崎病或新型冠状病毒肺炎(COVID- 19)的治 疗策略,一些新的治疗方案也不断出现。文章综述MIS-C诊疗相关研究现状与进展。

关键词: 多系统炎症综合征; 类川崎病; 严重急性呼吸综合征冠状病毒2; 新型冠状病毒肺炎; 儿童

Abstract: Multisystem inflammatory syndrome in children (MIS-C) is a severe inflammatory syndrome diagnosed as Kawasaki-like disease manifested by toxic shock and cardiogenic or vascular paralytic shock. MIS-C usually has atypical onset age (older) and ethnic background (non-Asian). MIS-C is a severe condition and can progress rapidly and deteriorate in a short time. MIS-C is potentially associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2 ). Since the pathogenesis of MIS-C is unclear, the treatments of MIS-C are based on treatment strategies in Kawasaki disease or coronavirus disease 2019 (COVID- 19 ), and it is reported some of new treatment strategies are effective. This article reviews the status and progress of diagnosis and treatment for MIS-C.

Key words: multisystem inflammatory syndrome; Kawasaki-like disease; severe acute respiratory syndrome coronavirus 2; coronavirus disease 2019; child