重度β-地中海贫血患儿脾脏切除术前后铁负荷的变化

临床儿科杂志 ›› 2014, Vol. 32 ›› Issue (4): 343-345.

重度β-地中海贫血患儿脾脏切除术前后铁负荷的变化

金伶，龙兴江，袁大华，杨彤，黄献文

广西柳州市人民医院儿科（广西柳州　545006）

收稿日期:2013-11-28 出版日期:2014-04-15 发布日期:2014-04-15

Changes of iron overload in children with severe beta-thalassaemia pre- and post-splenectomy　

JIN Ling, LONG Xingjiang, YUAN Dahua, YANG Tong, HUANG Xianwen

(Department of Pediatrics, Liuzhou People's Hospital, Liuzhou 545006, Guangxi, China)

Received:2013-11-28 Published:2014-04-15 Online:2014-04-15

摘要/Abstract

摘要：

　目的　探讨重度β-地中海贫血患儿脾脏切除术前后铁负荷状况的变化。方法　回顾性分析2003年1月至2012年12月18例重度β-地中海贫血患儿行脾切除术前、后的年输血量及血清铁蛋白水平。结果　重度β-地中海贫血患儿脾切除术后第1年和第2年的平均年输血量为（101.94±30.73）ml/kg和（96.50±34.00）ml/kg，均分别低于脾切除术前2年（241.89±73.66）ml/kg和前1年（289.22±102.30）ml/kg的年输血量，差异均有统计学意义（P<0.05）。脾切除术后6、12、18和24个月患儿的血清铁蛋白（SF）水平分别为（2 410.00±731.77）μg/L、（2 742.78±813.74）μg/L、（2 870.56±740.94）μg/L和（2 886.67±795.34）μg/L，均低于脾切除术前SF水平[（4 975.00±1 245.85）μg/L]，差异均有统计学意义（P<0.05）。结论　行脾切除术后β-地中海贫血患儿血清铁蛋白水平较前降低，但仍远高于正常值，需持续监测及去铁治疗。

Abstract: 　Objective　To explore the changes of iron overload in children with severe β-thalassemia pre- and post-splenectomy. Method The annual amount of blood transfused and serum ferritin (SF) levels of 18 children with severe β-thalassemia before and after splenectomy from January 2003 to December 2012 were retrospectively analyzed. Result The annual amount of blood transfused in children with severe β-thalassemia at one year and two years after splenectomy were (101.94±30.73) ml/kg and (96.50±34.00) ml/kg respectively, significantly lower than the amount of two years before splenectomy (241.89±73.66) ml/kg and one year before splenectomy (289.22±102.30) ml/kg (P<0.05). The SF levels at 6, 12, 18 and 24 months after splenectomy were (2 410.00±731.77) μg/L, (2 742.78±813.74) μg/L, (2 870.56±740.94) μg/L and (2 886.67±795.34) μg/L, significantly lower than that (4 975.00±1 245.85) μg/L of before splenectomy (P<0.05). Conclusions The serum ferritin level after splenectomy significantly decreases compared with that of before splenectomy, but still remarkably higher than that of normal controls. Monitoring of serum ferritin level and iron-chelating therapy are needed.

金伶，龙兴江，袁大华，杨彤，黄献文. 重度β-地中海贫血患儿脾脏切除术前后铁负荷的变化[J]. 临床儿科杂志, 2014, 32(4): 343-345.

JIN Ling,LONG Xingjiang,YUAN Dahua,YANG Tong,HUANG Xianwen. Changes of iron overload in children with severe beta-thalassaemia pre- and post-splenectomy　[J]. , 2014, 32(4): 343-345.

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