儿童特应性皮炎严重度与维生素D 水平的相关性

doi:10.3969/j.issn.1000-3606.2019.10.002

临床儿科杂志 ›› 2019, Vol. 37 ›› Issue (10): 727-.doi: 10.3969/j.issn.1000-3606.2019.10.002

儿童特应性皮炎严重度与维生素D 水平的相关性

李梅云 1，　谢丽 2，　何欢 1，　程颖 1，　刘晓依 1，　张珍 1，　陈琢 1，　陈戟 1

1.上海交通大学医学院附属儿童医学中心皮肤科（上海　200127）；2.上海交通大学医学院临床研究中心（上海　200025）

发布日期:2020-01-22
通讯作者: 陈戟　电子信箱：chenji1678@sina.com
基金资助:
上海交通大学附属儿童医学中心院级课题（No.YJ-SCMC2017-12）

The correlation between severity of atopic dermatitis and vitamin D level in children

　LI Meiyun1, XIE Li2, HE Huan1, CHENG Ying1, LIU Xiaoyi1, ZHANG Zhen1, CHEN Zhuo1, CHEN Ji1

1.Department of Dermatology, Shanghai Children’s Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; 2.Clinical Research Center, Shanghai Jiao Tong University, Shanghai 200127, China

Published:2020-01-22

摘要/Abstract

摘要： 目的　探讨儿童特应性皮炎（AD）疾病严重程度与维生素D水平的相关性。方法　纳入152例AD患儿，以 AD严重程度评分（SCORAD）评估AD严重度，液相色谱-串联质谱法检测血清25-羟维生素D[25(OH)D]，分析AD严重程度与血清25(OH)D水平的相关性。结果　152例AD患儿中，男81例、女71例，中位年龄3.5岁。轻度、中度、重度AD 患儿分别为 51例（33.6%）、80例（52.6%）、19 例（12.5%）。血清25(OH)D充足55 例（36.2%），不足65 例（42.8%），缺乏32 例（21.1%）。AD患儿SCORAD评分与血清25(OH)D水平无显著相关性（r=－0.047， P=0.567），与血清总IgE呈显著正相关（r=0.244， P=0.003），与血嗜酸性粒细胞比例呈显著正相关（r=0.239， P=0.004）。结论　AD儿童中血清维生素D缺乏和不足者较多，但AD的严重程度与血清25(OH)D水平无显著相关性。

关键词: 特应性皮炎；　维生素D；总IgE；　疾病严重程度指数；　儿童　

Abstract: Objective To study the correlation of serum vitamin D [25(OH)D] levels with the severity of childhood atopic dermatitis (AD). Methods　A total of 152 children with AD were enrolled. The severity of AD was assessed by SCORAD. Serum 25(OH)D levels were determined by liquid chromatography tandem mass spectrometry (LC-MS/MS). The correlation between the severity of AD and serum 25 (OH) D levels was analyzed. Results　In the 152 children (81 males, 71 females) with AD, the median age was 3.5 years. There were 51 cases of mild AD (33.6%), 80 cases of moderate AD (52.6%), and 19 cases of severe AD (12.5%). Vitamin D was sufficient in 55 cases (36.2%), insufficient in 65 cases (42.8%), and deficient in 32 cases (21.1%). The SCORAD score in children with AD was not correlated with serum 25 (OH) D levels (r=?0.047, P=0.567), while positively correlated with total serum IgE (r=0.244, P=0.003) and the percentage of blood eosinophils (r=0.239, P=0.004). Conclusions　Serum vitamin D insufficiency and deficiency were more common in AD children, but the severity of AD was not significantly correlated with serum 25 (OH) D levels.

Key words: 　atopic dermatitis;　vitamin D;　25-hydroxyvitamin D;　children;　total IgE;　severity of illness index

李梅云，谢丽，何欢，等. 儿童特应性皮炎严重度与维生素D 水平的相关性[J]. 临床儿科杂志, 2019, 37(10): 727-.

LI Meiyun, XIE Li, HE Huan, et al. The correlation between severity of atopic dermatitis and vitamin D level in children[J]. Journal of Clinical Pediatrics, 2019, 37(10): 727-.

儿童特应性皮炎严重度与维生素D 水平的相关性

The correlation between severity of atopic dermatitis and vitamin D level in children

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