脂质链长度与特应性皮炎相关性研究进展

doi:10.12372/jcp.2024.23e0567

临床儿科杂志 ›› 2024, Vol. 42 ›› Issue (1): 80-84.doi: 10.12372/jcp.2024.23e0567

• 文献综述 • 上一篇

脂质链长度与特应性皮炎相关性研究进展

夏欣综述¹^,²^,³, 姚志荣审校¹^,²^,³

1.上海交通大学医学院附属新华医院皮肤病中心（上海 200092）
2.上海交通大学医学院附属新华医院皮肤科（上海 200092）
3.上海交通大学医学院皮肤病研究所（上海 200092）

收稿日期:2023-06-27 出版日期:2024-01-15 发布日期:2024-01-05
基金资助:
中国国家自然科学基金(82203937);中国国家自然科学基金(No.82103716)

Research progress on lipid chain length and atopic dermatitis

XIA Xin¹^,²^,³, YAO Zhirong¹^,²^,³

1. Dermatology Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
2. Department of Dermatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
3. Institute of Dermatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China

Received:2023-06-27 Online:2024-01-15 Published:2024-01-05

摘要/Abstract

摘要：

特应性皮炎（atopic dermatitis, AD）是一种慢性、复发性炎症性皮肤病。越来越多证据表明，皮肤屏障功能障碍是导致AD的重要原因。皮肤最外层的脂质基质角质层（stratum corneum, SC）对皮肤屏障功能的维系至关重要。大量研究显示，角质层脂质含量降低、链长度缩短、神经酰胺（ceramide, CER）亚类水平改变以及炎症反应等都会影响AD患者皮肤屏障功能。本文就角质层脂质链长度与AD患者皮肤屏障功能的关系做一综述。

关键词: 角质层脂质, 脂肪酸链长度, 皮肤屏障, 特应性皮炎

Abstract:

Atopic dermatitis (AD) is a chronic and recurrent inflammatory skin disease. There is growing evidence that skin barrier dysfunction is an important cause of AD. The lipid matrix in the outermost layer of the skin, namely the stratum corneum (SC), is essential for the skin barrier function. A large number of studies have shown that the decrease of SC lipid content, the shortening of chain length, the change of ceramide (CER) subclass levels and inflammatory responses all affect the skin barrier function of AD patients. This article reviews the relationship between the SC lipid chain length and the skin barrier function in AD patients.

Key words: stratum corneum lipid, fatty acid chain length, skin barrier, atopic dermatitis

夏欣综述, 姚志荣审校. 脂质链长度与特应性皮炎相关性研究进展[J]. 临床儿科杂志, 2024, 42(1): 80-84.

XIA Xin, YAO Zhirong. Research progress on lipid chain length and atopic dermatitis[J]. Journal of Clinical Pediatrics, 2024, 42(1): 80-84.

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脂质链长度与特应性皮炎相关性研究进展

Research progress on lipid chain length and atopic dermatitis

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