临床儿科杂志 ›› 2018, Vol. 36 ›› Issue (7): 505-.doi: 10.3969/j.issn.1000-3606.2018.07.007

• 综合报道 • 上一篇    下一篇

不同胎龄早产儿支气管肺发育不良发生率及肺功能分析

吉玲, 冯姝华, 杨赟, 王慧娟   

  1. 郑州大学第三附属医院新生儿科(河南郑州 450052)
  • 收稿日期:2018-07-15 出版日期:2018-07-15 发布日期:2018-07-15
  • 通讯作者: 吉玲  E-mail:jiling1225@126.com

Incidence and lung function of bronchopulmonary dysplasia in premature infants with different gestational age

JI Ling, FENG Shuhua, YANG Yun, WANG Huijuan   

  1. Department of Neonatology, The Third Affiliated Hospital of Zhengzhou University, Zheng- zhou 450052, Henan, China
  • Received:2018-07-15 Online:2018-07-15 Published:2018-07-15

摘要:  目的 探讨不同胎龄早产儿支气管肺发育不良(BPD)的发生率、高危因素及其潮气呼吸肺功能特征。方 法 回顾分析近4年早产儿BPD发生情况,并按照严重程度分为轻、中、重度BPD,比较分析其潮气呼吸肺功能。结果 在8 538例早产儿中发生BPD 355例,发生率为4.16%。其中<28周早产儿为33.91%,28~32周8.85%,32~34周1.63%、 34~37周0.31%。轻度BPD患儿243例、中度51例、重度61例。不同程度BPD患儿的胎龄、出生体质量、住院时间、吸氧 时间、机械通气时间差异均有统计学意义(P<0.05);不同程度BPD患儿潮气呼吸肺功能分析中达峰时间比(27.73±9.26、 21.43±5.73、16.15±4.90)、达峰容积比(27.13±5.09、22.30±2.65、18.54±3.76)差异也有统计学意义(P均 <0.01)。 结论 BPD的发生与胎龄相关;BPD患儿有不同程度的潮气呼吸肺功能受损,其程度越重,潮气呼吸肺功能受 限越明显。

Abstract:  Objective To explore the incidence, risk factors and tidal breathing pulmonary function of bronchopulmonary dysplasia (BPD) in premature infants with different gestational age. Method The incidence of BPD in preterm infants in recent 4 years was analyzed retrospectively. Tidal breathing pulmonary function was compared among mild, moderate and severe BPD. Results In 8538 premature infants, BPD occurred in 355 infants (4.16%). The incidence rates of BPD in preterm infants with different gestational age were 33.91% (<28 weeks), 8.85% (28~32 weeks), 1.63% (32~34 weeks) and 0.31% (34~37 weeks) respectively. There were 243 cases of mild BPD, 51 cases of moderate BPD and 61 cases of severe BPD. There were statistically significant differences in the gestational age, birth weight, hospitalization time, oxygen inhalation time and mechanical ventilation time among children with different severity of BPD (all P<0.05). The peak time ratio (27.73±9.26、21.43±5.73、16.15±4.90), and peak volume ratio (27.13±5.09、22.30±2.65、18.54±3.76) in the analysis of tidal breathing and lung function were also significantly different among children with different severity of BPD (all P<0.01). Conclusion The incidence of BPD is related to the gestational age. Children with BPD had different degrees of damage in tidal breathing pulmonary function, and the more severe BPD has the more obvious limitation of tidal breathing pulmonary function.