Abstract: Objective　To investigate the screening value of glomerular hyperfiltration (GHF) in early renal damage of type 1 diabetes. Methods　The estimated glomerular filtration (eGFR) was calculated using the Macisaac’s equation in 100 cases of type 1 diabetes. According to eGFR’s level, the diabetes were divide into two groups: Normo-GFR group, 57 cases; and GHF group , 43 cases. The age, course of disease, glycosylated hemoglobin (HbA1c)、triglyceride (TG), renal glomerular damage indexes (UACR), and renal tubular damage indexes (urinary NAG/Cr, urinary α1-MG/Cr and serum NGAL) of each group were observed. Results　The HbA1c and TG values in the GHF group was significantly higher than those in the Normo-GFR group(P＜0.05). Serum NGAL values in the GHF group was significantly lower than those in the Normo-GFR group (P＞0.05). The UACR, urine NAG/Cr and urine α1-MG/Cr values between the GHF group and Normo-GFR group were not significantly different. Logistic regression analysis showed shorter diabetes duration and higher HbA1c levels were important influence factors of whether diabetes patients had hyperfiltration. Conclusions　GHF may reflect abnormal glucose and lipid metabolism that could be detected at early stage of the type 1 diabetes, but its independent correlation with diabetic kidney damage needs further research.