Abstract: Objective　To explore  the differences of the clinicopathological characteristics of children with hepatoblastoma (HB). Methods　Clinical data of 68 patients with HB confirmed by surgery and pathology in Xinhua Hospital were retrospectively analyzed. Results　In the 68 children (44 males and 24 females) with HB, 55 cases were under 3 years of age, and 13 cases older than 3 years. The patients presented with elevated AFP level and unifocal lesions when diagnosed. 27 patients were classified into high risk group according to SIOPEL, and 13 patients were in PRETEXT Ⅳ stage according to imaging results before operation. There are 22 children with metastases and/or extrahepatic abdominal diseases and/or involvement of the main portal vein or of all three hepatic veins and/or the IVC. There was an obvious relationship between PRETEXT staging and the age, the level of AFP and the pathological classification. (P<0.05). There was an obvious relationship between the pathological classification and the level of AFP (P=0.002).  The pathological classification showed association with AFP level (P=0.002). There was also an obvious relationship between the pathological classification and the risk classification (P=0.043). Conclusions　The difference of clinicopathological features in children with hepatoblastoma may help to guide clinical treatment and prognostic evaluation.