他克莫司与环孢素 A 治疗难治性肾病综合征疗效的 meta 分析#br#

doi:10.3969/j.issn.1000-3606.2018.10.016

临床儿科杂志 ›› 2018, Vol. 36 ›› Issue (10): 791-.doi: 10.3969/j.issn.1000-3606.2018.10.016

他克莫司与环孢素 A 治疗难治性肾病综合征疗效的 meta 分析#br#

文敏,　党西强

中南大学湘雅二医院儿童医学中心（湖南长沙　410011）

收稿日期:2018-10-15 出版日期:2018-10-15 发布日期:2018-10-15
通讯作者: 党西强 E-mail:dangxiqiang@csu.edu.cn

The efficacy of tacrolimus and cyclosporine A in the treatment of refractory nephrotic syndrome: a meta-analysis

WEN Min, DANG Xiqiang

Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China

Received:2018-10-15 Online:2018-10-15 Published:2018-10-15

摘要/Abstract

摘要： 　目的　评价他克莫司（TAC）与环孢素A（CsA）对难治性肾病综合征（RNS）治疗的有效性。方法　查阅 PubMed、Cochrane Library、万方、维普、中国期刊全文数据库(CNKI)计算机检索系统，检索2000年1月至2017年6月间发表的随机对照临床试验，以完全缓解率、总缓解率、复发率作为指标，采用RevMan 5.3软件进行meta分析。结果　共检索到相关文献426篇，根据纳入标准及排除标准，最终纳入6篇文献，共包括302例RNS患者。Meta分析结果示，TAC组较CsA组的完全缓解率（RR=2.01，95%CI：1.15~3.51， Z=2.44， P=0.01）、总缓解率（RR=2.53，95%CI：1.10~5.83， Z=2.19， P=0.03）的差异有统计学意义；复发率（RR=0.62，95%CI：0.30~1.27， Z=1.31， P=0.19）的差异无明显统计学意义。结论　与CsA相比，TAC在提高RNS的完全缓解率、总缓解率方面占有一定优势。

Abstract: 　Objective　To explore the efficacy of tacrolimus (TAC) and cyclosporine A (CsA) in the treatment of refractory nephrotic syndrome (RNS). Methods　The databases of PubMed, Cochrane Library, Wanfang, VIP, CNKI were searched to retrieve randomized controlled clinical trials published from January 2000 to June 2017. Meta-analysis was performed using RevMan 5.3 software using complete remission rate, overall remission rate and recurrence rate as indicators. Results　A total of 426 articles were retrieved. According to inclusion and exclusion criteria, 6 articles were finally included with 302 RNS patients in total. Meta-analysis showed that there were significant differences in complete remission rate (RR=2.01, 95%CI: 1.15~3.51, Z=2.44, P=0.01) and total remission rate (RR=2.53, 95%CI: 1.10~5.83, Z=2.19, P=0.03) while there was no difference in recurrence rate (RR=0.62, 95%CI: 0.30~1.27, Z=1.31, P=0.19) between TAC group and CsA group. Conclusion　Compared with CsA, TAC has certain advantage in improving the complete remission rate and total remission rate of RNS.

文敏,　党西强 . 他克莫司与环孢素 A 治疗难治性肾病综合征疗效的 meta 分析#br#[J]. 临床儿科杂志, 2018, 36(10): 791-.

WEN Min, DANG Xiqiang . The efficacy of tacrolimus and cyclosporine A in the treatment of refractory nephrotic syndrome: a meta-analysis[J]. , 2018, 36(10): 791-.

他克莫司与环孢素 A 治疗难治性肾病综合征疗效的 meta 分析#br#

The efficacy of tacrolimus and cyclosporine A in the treatment of refractory nephrotic syndrome: a meta-analysis

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