临床儿科杂志 ›› 2014, Vol. 32 ›› Issue (1): 80-82.

• 专家笔谈 • 上一篇    下一篇

人巨细胞病毒逃避NK细胞免疫机制研究进展

孙敏综述钱继红审校   

  1. 上海交通大学医学院附属新华医院新生儿科(上海 200092)
  • 收稿日期:2013-07-21 出版日期:2014-01-15 发布日期:2014-01-15

Progress of research in immune mechanism of human cytomegalovirus evasion of natural killer cells Reviewer: SUN Min, Reviser: QIAN Jihong (Department of Neonatology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China)

  • Received:2013-07-21 Published:2014-01-15 Online:2014-01-15

摘要:

 人巨细胞病毒(HCMV)属于疱疹病毒β亚家族,感染率高,分布广泛,原发感染后不易完全清除,导致长期的潜伏感染。自然杀伤(NK)细胞在抗病毒感染固有免疫中起到重要作用,HCMV长期潜伏期间采取一系列措施逃避NK细胞的杀伤,其免疫逃避机制十分复杂,如编码宿主基因同源物、微小RNA等。本文综述近年来对HCMV逃避NK细胞免疫机制的研究结果。

Abstract:  Human cytomegalovirus (HCMV) is a member of β-herpesvirus subfamily, with a high infection rate, worldwide spread. It can hardly be eliminated completely after primary infection, causing lifelong, persistent infections. NK cells play a vital role in the innate immunity. HCMV adopts a series of measures to avoid the NK cell killing. The immune evasion mechanism is very complicated, such as encoding host gene homologue, microRNA. This article review the mechanisms by which the HCMV evade the NK cell killing.