不同听力损失程度婴儿短声与短纯音听性脑干反应波Ⅴ潜伏期-强度函数构建

doi:10.12372/jcp.2025.25e0802

临床儿科杂志 ›› 2025, Vol. 43 ›› Issue (12): 908-914.doi: 10.12372/jcp.2025.25e0802

不同听力损失程度婴儿短声与短纯音听性脑干反应波Ⅴ潜伏期-强度函数构建

沈佳丽¹^,^*, 马孝宝¹^,^*, 汪玮¹, 王璐¹, 楼高忠², 赵哲弘³, 金玉莲¹, 杨军¹(), 陈建勇¹()

1.上海交通大学医学院附属新华医院耳鼻咽喉头颈外科上海交通大学医学院耳科学研究所上海市耳鼻疾病转化医学重点实验室（上海 200092）
2.杭州市妇幼保健院（杭州市儿童医院）耳鼻咽喉科（浙江杭州 310000）
3.绍兴市中心医院医共体总院耳鼻咽喉科（浙江绍兴 312030）

收稿日期:2025-07-10 录用日期:2025-09-01 出版日期:2025-12-15 发布日期:2025-11-28
通讯作者: 杨军，电子信箱：yangjun@xinhuamed.com.cn，陈建勇，电子信箱：chenjianyong@xinhuamed.com.cn
作者简介:^* 具有同等贡献
基金资助:
国家自然科学基金面上项目(82271179);国家自然科学基金面上项目(82230035);国家自然科学基金面上项目(82271160);国家重点研发计划(2024YFC2511100);上海交通大学医学院附属新华医院院级临床研究培育基金项目(21XHDB02)

Latency-intensity functions of wave Ⅴ in click and tone-burst auditory brainstem responses in infants with varying degrees of sensorineural hearing loss

SHEN Jiali¹^,^*, MA Xiaobao¹^,^*, WANG Wei¹, WANG Lu¹, LOU Gaozhong², ZHAO Zhehong³, JIN Yulian¹, YANG Jun¹(), CHEN Jianyong¹()

1. Department of Otolaryngology, Head and Neck Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Translational Medicine of Ear and Nose Disease, Shanghai 200092, China
2. Department of Otolaryngology, Hangzhou Maternity and Child Health Care Hospital, Hangzhou Children’s Hospital, Hangzhou 310000, Zhejiang, China
3. Department of Otolaryngology, Shaoxing Central Hospital, Shaoxing 312030, Zhejiang, China

Received:2025-07-10 Accepted:2025-09-01 Published:2025-12-15 Online:2025-11-28

摘要/Abstract

摘要：

目的构建不同听力损失程度感音神经性听力损失（SNHL）婴儿气导短声（click）听性脑干反应（c-ABR）与短纯音ABR（Tb-ABR）波Ⅴ潜伏期-强度函数，为临床ABR阈值判断提供参考。方法选取2023年1月至2025年5月在听力障碍及眩晕诊治中心就诊的3~12月龄婴儿作为研究对象，比较听力正常、轻度和中度SNHL三组婴儿在70 dB nHL及阈值强度下click及不同频率Tb-ABR（500、1 000 Hz）波Ⅴ潜伏期，并构建波Ⅴ潜伏期-强度函数。结果纳入婴儿120例，男52例、女68例，中位年龄为6（5~9）月龄。所有婴儿按照气导c-ABR阈值分为3组，其中听力正常组90耳、轻度SNHL组90耳、中度SNHL组60耳。70 dB nHL以及阈值强度下，c-ABR、Tb-500 Hz、Tb-1000 Hz ABR潜伏期在三组间的差异均有统计学意义（P<0.01）。70 dB nHL强度下，ABR潜伏期-强度函数模型分别为，c-ABR：Y=0.013X+6.07；Tb-500 Hz：Y=0.032X+9.09；Tb-1000 Hz：Y=0.022X+8.05。阈值强度下，ABR潜伏期-强度函数模型分别为，c-ABR：Y=－0.026X+8.98；Tb-500 Hz：Y=－0.057X+15.59；Tb-1000 Hz：Y=－0.052X+13.22。结论 c-ABR、Tb-500 Hz、Tb-1000 Hz ABR的波Ⅴ潜伏期与听力损失程度有关。本研究建立的click及不同频率Tb-ABR潜伏期-强度函数模型可为临床阈值判断提供参考。

关键词: 短声ABR, 短纯音ABR, 听力损失, 潜伏期-强度函数模型, 婴儿

Abstract:

Objective To construct the latency-intensity functions of air conduction click auditory brainstem response (c-ABR) and tone-burst ABR (Tb-ABR) waves in infants with varying degrees of sensorineural hearing loss (SNHL), providing a reference for the judgment of clinical ABR thresholds. Methods Infants aged 3 to 12 months who visited the Hearing Impairment and Vertigo Diagnosis and Treatment Center from January 2023 to May 2025 were selected as the research subjects. Wave Ⅴ latencies were compared among the three groups (normal hearing, mild SNHL, and moderate SNHL groups) under both 70 dB nHL and threshold-level intensities using c-ABR and Tb-ABR (500 Hz and 1000 Hz). Latency-intensity function models were then constructed. Results A total of 120 infants were enrolled, including 52 boys and 68 girls, with a median age of 6 (5-9) months. All infants were divided into three groups based on their air-conduction c-ABR thresholds: 90 ears in the normal hearing group, 90 ears in the mild SNHL group, and 60 ears in the moderate SNHL group. At 70 dB nHL and threshold intensity levels, significant differences in wave Ⅴ latencies were found among the three groups for c-ABR, Tb-500 Hz, and Tb-1000 Hz (P<0.01). Latency-intensity function models at 70 dB nHL were as follows, c-ABR: Y=0.013X+6.07; Tb-500 Hz: Y=0.032X+9.09; Tb-1000 Hz: Y=0.022X+8.05. Latency-intensity function models at threshold intensity levels were as follows, c-ABR: Y=－0.026X+8.98; Tb-500 Hz: Y=－0.057X+15.59; Tb-1000 Hz: Y=－0.052X+13.22. Conclusions Wave Ⅴ latencies in c-ABR, Tb-500 Hz, and Tb-1000 Hz are associated with the degree of hearing loss. The latency-intensity function models developed in this study can serve as objective references to aid clinical threshold estimation using ABR.

Key words: click ABR, tone-burst ABR, hearing loss, latency-intensity function model, infant

中图分类号:

沈佳丽, 马孝宝, 汪玮, 王璐, 楼高忠, 赵哲弘, 金玉莲, 杨军, 陈建勇. 不同听力损失程度婴儿短声与短纯音听性脑干反应波Ⅴ潜伏期-强度函数构建[J]. 临床儿科杂志, 2025, 43(12): 908-914.

SHEN Jiali, MA Xiaobao, WANG Wei, WANG Lu, LOU Gaozhong, ZHAO Zhehong, JIN Yulian, YANG Jun, CHEN Jianyong. Latency-intensity functions of wave Ⅴ in click and tone-burst auditory brainstem responses in infants with varying degrees of sensorineural hearing loss[J]. Journal of Clinical Pediatrics, 2025, 43(12): 908-914.

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参考文献 19

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组别	耳数	年龄[M(P₂₅~P₇₅)]/月	性别（男/女）
正常组	90	6(6~9)	40/50
轻度SNHL组	90	6(5~10)	36/54
中度SNHL组	60	6(3~9)	28/32
统计量		H=2.76	χ²=0.72
P		0.252	0.696

组别	耳数	c-ABR	Tb-500 Hz ABR	Tb-1000 Hz ABR	F值	P
正常组	90	6.30±0.33	10.59±0.95³⁾	8.77±0.73³⁾⁴⁾	861.14	<0.001
轻度SNHL组	90	6.58±0.62¹⁾	10.62±1.32³⁾	9.08±1.01¹⁾³⁾⁴⁾	375.43	<0.001
中度SNHL组	60	6.88±0.80¹⁾²⁾	11.14±1.18¹⁾²⁾³⁾	9.40±1.06^1)2)3)4)	262.08	<0.001
F值		17.81	5.20	7.70
P		<0.001	0.006	0.001

组别	耳数	c-ABR	Tb-500 Hz ABR	Tb-1000 Hz ABR	F值	P
正常组	90	8.51±0.59	13.45±1.07³⁾	11.55±0.96³⁾⁴⁾	761.81	<0.001
轻度SNHL组	90	8.06±0.92¹⁾	12.45±1.51¹⁾³⁾	10.68±1.36¹⁾³⁾⁴⁾	288.79	<0.001
中度SNHL组	60	7.23±0.77¹⁾²⁾	11.74±1.30¹⁾²⁾³⁾	9.91±1.21^1)2)3)4)	249.64	<0.001
F值		50.75	39.47	32.52
P		<0.001	<0.001	<0.001

不同听力损失程度婴儿短声与短纯音听性脑干反应波Ⅴ潜伏期-强度函数构建

Latency-intensity functions of wave Ⅴ in click and tone-burst auditory brainstem responses in infants with varying degrees of sensorineural hearing loss

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项目	强度	回归方程	R²	P
c-ABR	70 dB nHL	Y=0.013X+6.07	0.163	<0.001
c-ABR	阈值强度	Y=－0.026X+8.98	0.303	<0.001
Tb-500 Hz ABR	70 dB nHL	Y=0.032X+9.09	0.120	<0.001
Tb-500 Hz ABR	阈值强度	Y=－0.057X+15.59	0.244	<0.001
Tb-1000 Hz ABR	70 dB nHL	Y=0.022X+8.05	0.125	<0.001
Tb-1000 Hz ABR	阈值强度	Y=－0.052X+13.22	0.371	<0.001

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